Spatially restricted loading of BRD2 at DNA double-strand breaks protects H4 acetylation domains and promotes DNA repair

The n-terminal tail of histone H4 recruits repair proteins, including 53BP1, to DNA double-strand breaks (DSB) and undergoes dynamic acetylation during DSB repair. However, how H4 acetylation (H4Ac) recruits repair proteins and reorganizes chromatin during DNA repair is unclear. Here, we show that t...

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Detalles Bibliográficos
Autores principales: Gursoy-Yuzugullu, Ozge, Carman, Chelsea, Price, Brendan D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5635005/
https://www.ncbi.nlm.nih.gov/pubmed/29018219
http://dx.doi.org/10.1038/s41598-017-13036-5

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5635005/
https://www.ncbi.nlm.nih.gov/pubmed/29018219
http://dx.doi.org/10.1038/s41598-017-13036-5

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