Phyllomeroterpenoids A-C, Multi-biosynthetic Pathway Derived Meroterpenoids from the TCM Endophytic Fungus Phyllosticta sp. and their Antimicrobial Activities

Phyllomeroterpenoids A−C (1−3), multi-biosynthetic pathway derived meroterpenoids from amino acid/pentose phosphate/terpenoid pathways, were isolated from the TCM endophytic fungus Phyllosticta sp. J13-2-12Y, together with six biosynthetically related compounds (4−9). All structures were determined...

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Detalles Bibliográficos
Autores principales: Yang, Heng-Gang, Zhao, Huan, Li, Jiao-Jiao, Chen, Shao-Meng, Mou, Lang-Ming, Zou, Jian, Chen, Guo-Dong, Qin, Sheng-Ying, Wang, Chuan-Xi, Hu, Dan, Yao, Xin-Sheng, Gao, Hao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5635028/
https://www.ncbi.nlm.nih.gov/pubmed/29018263
http://dx.doi.org/10.1038/s41598-017-13407-y
Descripción
Sumario:Phyllomeroterpenoids A−C (1−3), multi-biosynthetic pathway derived meroterpenoids from amino acid/pentose phosphate/terpenoid pathways, were isolated from the TCM endophytic fungus Phyllosticta sp. J13-2-12Y, together with six biosynthetically related compounds (4−9). All structures were determined by extensive spectroscopic analysis, chemical derivatization, and ECD experiments. A plausible biosynthetic pathway of 1−3 was proposed. In addition, the antimicrobial activities of all isolated compounds were evaluated against Staphylococcus aureus 209P (bacterium) and Candida albicans FIM709 (fungus).

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