Phyllomeroterpenoids A-C, Multi-biosynthetic Pathway Derived Meroterpenoids from the TCM Endophytic Fungus Phyllosticta sp. and their Antimicrobial Activities

Phyllomeroterpenoids A−C (1−3), multi-biosynthetic pathway derived meroterpenoids from amino acid/pentose phosphate/terpenoid pathways, were isolated from the TCM endophytic fungus Phyllosticta sp. J13-2-12Y, together with six biosynthetically related compounds (4−9). All structures were determined...

Descripción completa

Detalles Bibliográficos
Autores principales: Yang, Heng-Gang, Zhao, Huan, Li, Jiao-Jiao, Chen, Shao-Meng, Mou, Lang-Ming, Zou, Jian, Chen, Guo-Dong, Qin, Sheng-Ying, Wang, Chuan-Xi, Hu, Dan, Yao, Xin-Sheng, Gao, Hao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5635028/
https://www.ncbi.nlm.nih.gov/pubmed/29018263
http://dx.doi.org/10.1038/s41598-017-13407-y
_version_ 1783270199445684224
author Yang, Heng-Gang
Zhao, Huan
Li, Jiao-Jiao
Chen, Shao-Meng
Mou, Lang-Ming
Zou, Jian
Chen, Guo-Dong
Qin, Sheng-Ying
Wang, Chuan-Xi
Hu, Dan
Yao, Xin-Sheng
Gao, Hao
author_facet Yang, Heng-Gang
Zhao, Huan
Li, Jiao-Jiao
Chen, Shao-Meng
Mou, Lang-Ming
Zou, Jian
Chen, Guo-Dong
Qin, Sheng-Ying
Wang, Chuan-Xi
Hu, Dan
Yao, Xin-Sheng
Gao, Hao
author_sort Yang, Heng-Gang
collection PubMed
description Phyllomeroterpenoids A−C (1−3), multi-biosynthetic pathway derived meroterpenoids from amino acid/pentose phosphate/terpenoid pathways, were isolated from the TCM endophytic fungus Phyllosticta sp. J13-2-12Y, together with six biosynthetically related compounds (4−9). All structures were determined by extensive spectroscopic analysis, chemical derivatization, and ECD experiments. A plausible biosynthetic pathway of 1−3 was proposed. In addition, the antimicrobial activities of all isolated compounds were evaluated against Staphylococcus aureus 209P (bacterium) and Candida albicans FIM709 (fungus).
format Online
Article
Text
id pubmed-5635028
institution National Center for Biotechnology Information
language English
publishDate 2017
publisher Nature Publishing Group UK
record_format MEDLINE/PubMed
spelling pubmed-56350282017-10-18 Phyllomeroterpenoids A-C, Multi-biosynthetic Pathway Derived Meroterpenoids from the TCM Endophytic Fungus Phyllosticta sp. and their Antimicrobial Activities Yang, Heng-Gang Zhao, Huan Li, Jiao-Jiao Chen, Shao-Meng Mou, Lang-Ming Zou, Jian Chen, Guo-Dong Qin, Sheng-Ying Wang, Chuan-Xi Hu, Dan Yao, Xin-Sheng Gao, Hao Sci Rep Article Phyllomeroterpenoids A−C (1−3), multi-biosynthetic pathway derived meroterpenoids from amino acid/pentose phosphate/terpenoid pathways, were isolated from the TCM endophytic fungus Phyllosticta sp. J13-2-12Y, together with six biosynthetically related compounds (4−9). All structures were determined by extensive spectroscopic analysis, chemical derivatization, and ECD experiments. A plausible biosynthetic pathway of 1−3 was proposed. In addition, the antimicrobial activities of all isolated compounds were evaluated against Staphylococcus aureus 209P (bacterium) and Candida albicans FIM709 (fungus). Nature Publishing Group UK 2017-10-10 /pmc/articles/PMC5635028/ /pubmed/29018263 http://dx.doi.org/10.1038/s41598-017-13407-y Text en © The Author(s) 2017 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
spellingShingle Article
Yang, Heng-Gang
Zhao, Huan
Li, Jiao-Jiao
Chen, Shao-Meng
Mou, Lang-Ming
Zou, Jian
Chen, Guo-Dong
Qin, Sheng-Ying
Wang, Chuan-Xi
Hu, Dan
Yao, Xin-Sheng
Gao, Hao
Phyllomeroterpenoids A-C, Multi-biosynthetic Pathway Derived Meroterpenoids from the TCM Endophytic Fungus Phyllosticta sp. and their Antimicrobial Activities
title Phyllomeroterpenoids A-C, Multi-biosynthetic Pathway Derived Meroterpenoids from the TCM Endophytic Fungus Phyllosticta sp. and their Antimicrobial Activities
title_full Phyllomeroterpenoids A-C, Multi-biosynthetic Pathway Derived Meroterpenoids from the TCM Endophytic Fungus Phyllosticta sp. and their Antimicrobial Activities
title_fullStr Phyllomeroterpenoids A-C, Multi-biosynthetic Pathway Derived Meroterpenoids from the TCM Endophytic Fungus Phyllosticta sp. and their Antimicrobial Activities
title_full_unstemmed Phyllomeroterpenoids A-C, Multi-biosynthetic Pathway Derived Meroterpenoids from the TCM Endophytic Fungus Phyllosticta sp. and their Antimicrobial Activities
title_short Phyllomeroterpenoids A-C, Multi-biosynthetic Pathway Derived Meroterpenoids from the TCM Endophytic Fungus Phyllosticta sp. and their Antimicrobial Activities
title_sort phyllomeroterpenoids a-c, multi-biosynthetic pathway derived meroterpenoids from the tcm endophytic fungus phyllosticta sp. and their antimicrobial activities
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5635028/
https://www.ncbi.nlm.nih.gov/pubmed/29018263
http://dx.doi.org/10.1038/s41598-017-13407-y
work_keys_str_mv AT yanghenggang phyllomeroterpenoidsacmultibiosyntheticpathwayderivedmeroterpenoidsfromthetcmendophyticfungusphyllostictaspandtheirantimicrobialactivities
AT zhaohuan phyllomeroterpenoidsacmultibiosyntheticpathwayderivedmeroterpenoidsfromthetcmendophyticfungusphyllostictaspandtheirantimicrobialactivities
AT lijiaojiao phyllomeroterpenoidsacmultibiosyntheticpathwayderivedmeroterpenoidsfromthetcmendophyticfungusphyllostictaspandtheirantimicrobialactivities
AT chenshaomeng phyllomeroterpenoidsacmultibiosyntheticpathwayderivedmeroterpenoidsfromthetcmendophyticfungusphyllostictaspandtheirantimicrobialactivities
AT moulangming phyllomeroterpenoidsacmultibiosyntheticpathwayderivedmeroterpenoidsfromthetcmendophyticfungusphyllostictaspandtheirantimicrobialactivities
AT zoujian phyllomeroterpenoidsacmultibiosyntheticpathwayderivedmeroterpenoidsfromthetcmendophyticfungusphyllostictaspandtheirantimicrobialactivities
AT chenguodong phyllomeroterpenoidsacmultibiosyntheticpathwayderivedmeroterpenoidsfromthetcmendophyticfungusphyllostictaspandtheirantimicrobialactivities
AT qinshengying phyllomeroterpenoidsacmultibiosyntheticpathwayderivedmeroterpenoidsfromthetcmendophyticfungusphyllostictaspandtheirantimicrobialactivities
AT wangchuanxi phyllomeroterpenoidsacmultibiosyntheticpathwayderivedmeroterpenoidsfromthetcmendophyticfungusphyllostictaspandtheirantimicrobialactivities
AT hudan phyllomeroterpenoidsacmultibiosyntheticpathwayderivedmeroterpenoidsfromthetcmendophyticfungusphyllostictaspandtheirantimicrobialactivities
AT yaoxinsheng phyllomeroterpenoidsacmultibiosyntheticpathwayderivedmeroterpenoidsfromthetcmendophyticfungusphyllostictaspandtheirantimicrobialactivities
AT gaohao phyllomeroterpenoidsacmultibiosyntheticpathwayderivedmeroterpenoidsfromthetcmendophyticfungusphyllostictaspandtheirantimicrobialactivities

Ejemplares similares