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S1P(1) deletion differentially affects TH17 and Regulatory T cells

Sphingosine-1 phosphate receptor 1 (S1P(1)) is critical for the egress of T and B cells out of lymphoid organs. Although S1P(1) agonist fingolimod is currently used for the treatment of multiple sclerosis (MS) little is known how S1P(1) signaling regulates Th17 and T(reg) cell homeostasis. To study...

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Detalles Bibliográficos
Autores principales:	Eken, Ahmet, Duhen, Rebekka, Singh, Akhilesh K., Fry, Mallory, Buckner, Jane H., Kita, Mariko, Bettelli, Estelle, Oukka, Mohamed
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2017
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5635040/ https://www.ncbi.nlm.nih.gov/pubmed/29018225 http://dx.doi.org/10.1038/s41598-017-13376-2

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