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Effects of Acupuncture on Alzheimer's Disease in Animal-Based Research
Alzheimer's disease (AD) is a chronic neurodegenerative disease characterized by the accumulation of amyloid beta (Aβ) plaques, neurofibrillary tangles, and severe functional deficits in the brain. The pathogenesis and treatment of AD remain topics of investigation and significant global socioe...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Hindawi
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5635287/ https://www.ncbi.nlm.nih.gov/pubmed/29234418 http://dx.doi.org/10.1155/2017/6512520 |
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author | Park, Sunjung Lee, Jun-Hwan Yang, Eun Jin |
author_facet | Park, Sunjung Lee, Jun-Hwan Yang, Eun Jin |
author_sort | Park, Sunjung |
collection | PubMed |
description | Alzheimer's disease (AD) is a chronic neurodegenerative disease characterized by the accumulation of amyloid beta (Aβ) plaques, neurofibrillary tangles, and severe functional deficits in the brain. The pathogenesis and treatment of AD remain topics of investigation and significant global socioeconomic issues. The effect of complementary medicine has been investigated in managing AD. Acupuncture, a form of therapy practiced for more than 3000 years, has shown positive effects on several neurological disorders including AD. Animal studies have evaluated the specific utility and neuropathological mechanisms addressed by acupoint manipulation; however, no study has summarized the relationships among different acupoints and their therapeutic effects in the context of AD. Therefore, we reviewed the effects of acupuncture at different acupoints in animal models of AD. In general, acupuncture produced therapeutic benefits in rodent models of AD. Studies demonstrate the utility of GV20 as a valuable acupoint for electroacupuncture and manual acupuncture. GV20 stimulation suppresses Aβ generation, improves glucose metabolism, and attenuates neuropathological features in various disease models. However, a lack of sufficient evidence in preclinical and clinical studies makes these results controversial. Additional studies are required to confirm the exact utility of specific acupoints in clinically managing AD. |
format | Online Article Text |
id | pubmed-5635287 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | Hindawi |
record_format | MEDLINE/PubMed |
spelling | pubmed-56352872017-12-11 Effects of Acupuncture on Alzheimer's Disease in Animal-Based Research Park, Sunjung Lee, Jun-Hwan Yang, Eun Jin Evid Based Complement Alternat Med Review Article Alzheimer's disease (AD) is a chronic neurodegenerative disease characterized by the accumulation of amyloid beta (Aβ) plaques, neurofibrillary tangles, and severe functional deficits in the brain. The pathogenesis and treatment of AD remain topics of investigation and significant global socioeconomic issues. The effect of complementary medicine has been investigated in managing AD. Acupuncture, a form of therapy practiced for more than 3000 years, has shown positive effects on several neurological disorders including AD. Animal studies have evaluated the specific utility and neuropathological mechanisms addressed by acupoint manipulation; however, no study has summarized the relationships among different acupoints and their therapeutic effects in the context of AD. Therefore, we reviewed the effects of acupuncture at different acupoints in animal models of AD. In general, acupuncture produced therapeutic benefits in rodent models of AD. Studies demonstrate the utility of GV20 as a valuable acupoint for electroacupuncture and manual acupuncture. GV20 stimulation suppresses Aβ generation, improves glucose metabolism, and attenuates neuropathological features in various disease models. However, a lack of sufficient evidence in preclinical and clinical studies makes these results controversial. Additional studies are required to confirm the exact utility of specific acupoints in clinically managing AD. Hindawi 2017 2017-09-27 /pmc/articles/PMC5635287/ /pubmed/29234418 http://dx.doi.org/10.1155/2017/6512520 Text en Copyright © 2017 Sunjung Park et al. https://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Review Article Park, Sunjung Lee, Jun-Hwan Yang, Eun Jin Effects of Acupuncture on Alzheimer's Disease in Animal-Based Research |
title | Effects of Acupuncture on Alzheimer's Disease in Animal-Based Research |
title_full | Effects of Acupuncture on Alzheimer's Disease in Animal-Based Research |
title_fullStr | Effects of Acupuncture on Alzheimer's Disease in Animal-Based Research |
title_full_unstemmed | Effects of Acupuncture on Alzheimer's Disease in Animal-Based Research |
title_short | Effects of Acupuncture on Alzheimer's Disease in Animal-Based Research |
title_sort | effects of acupuncture on alzheimer's disease in animal-based research |
topic | Review Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5635287/ https://www.ncbi.nlm.nih.gov/pubmed/29234418 http://dx.doi.org/10.1155/2017/6512520 |
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