Renal Cell Carcinoma and a Pancreatic Neuroendocrine Tumor: A Coincidence or Instance of Von Hippel-Lindau Disease?

We herein report a rare case of a 79-year-old man who presented with the simultaneous occurrence of pancreatic neuroendocrine tumors (PNET) and renal cell carcinomas (RCC), without any other Von Hippel-Lindau (VHL)-associated lesions or any pertinent family history. Computed tomography showed vascul...

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Detalles Bibliográficos
Autores principales: Matsubayashi, Hiroyuki, Niwakawa, Masashi, Uesaka, Katsuhiko, Sasaki, Keiko, Kiyozumi, Yoshimi, Ishiwatari, Hirotoshi, Hotta, Kinichi, Imai, Kenichiro, Ito, Sayo, Takizawa, Kohei, Tanaka, Masaki, Kawata, Noboru, Kakushima, Naomi, Ono, Hiroyuki
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Japanese Society of Internal Medicine 2017
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5635299/
https://www.ncbi.nlm.nih.gov/pubmed/28794363
http://dx.doi.org/10.2169/internalmedicine.8347-16
Descripción
Sumario:We herein report a rare case of a 79-year-old man who presented with the simultaneous occurrence of pancreatic neuroendocrine tumors (PNET) and renal cell carcinomas (RCC), without any other Von Hippel-Lindau (VHL)-associated lesions or any pertinent family history. Computed tomography showed vascular-rich solid lesions in the left kidney and the pancreatic tail, measuring 72 mm and 15 mm in size, respectively. Preoperatively, RCC with pancreatic metastasis was suspected and laparotomy was performed. However, the resected specimens revealed a different tumor histology, namely renal clear cell carcinoma (G2, pT3) and PNET (G1, pT3). The patient and his family refused genetic testing, however, so far, the patient has not developed any VHL-associated lesions for more than four years.

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