Successful Treatment with Alectinib for Choroidal Metastasis in Anaplastic Lymphoma Kinase Rearranged Non-small Cell Lung Cancer

Choroidal metastasis is rare in cancer patients and it may cause visual disturbances that reduce their quality of life. In non-small cell lung cancer (NSCLC), targeted therapy against actionable driver mutations has gradually replaced radiotherapy as the treatment of choice for choroidal metastasis....

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Autores principales: Funazo, Tomoko, Morita, Kyohei, Ikegami, Naoya, Konishi, Chisato, Nakao, Satoshi, Ariyasu, Ryo, Taki, Masato, Nakagawa, Kazuhiko, Hwang, Moon Hee, Yoshimura, Chie, Wakayama, Toshiaki, Nishizaka, Yasuo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Japanese Society of Internal Medicine 2017
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5635306/
https://www.ncbi.nlm.nih.gov/pubmed/28794371
http://dx.doi.org/10.2169/internalmedicine.8488-16
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author Funazo, Tomoko
Morita, Kyohei
Ikegami, Naoya
Konishi, Chisato
Nakao, Satoshi
Ariyasu, Ryo
Taki, Masato
Nakagawa, Kazuhiko
Hwang, Moon Hee
Yoshimura, Chie
Wakayama, Toshiaki
Nishizaka, Yasuo
author_facet Funazo, Tomoko
Morita, Kyohei
Ikegami, Naoya
Konishi, Chisato
Nakao, Satoshi
Ariyasu, Ryo
Taki, Masato
Nakagawa, Kazuhiko
Hwang, Moon Hee
Yoshimura, Chie
Wakayama, Toshiaki
Nishizaka, Yasuo
author_sort Funazo, Tomoko
collection PubMed
description Choroidal metastasis is rare in cancer patients and it may cause visual disturbances that reduce their quality of life. In non-small cell lung cancer (NSCLC), targeted therapy against actionable driver mutations has gradually replaced radiotherapy as the treatment of choice for choroidal metastasis. Recently, there have been several case reports of choroidal metastasis in patients with anaplastic lymphoma kinase (ALK)-rearranged NSCLC. We herein report the case of a 40-year-old Japanese woman diagnosed with choroidal metastasis of an ALK-rearranged NSCLC who received alectinib as the first-line chemotherapy. Alectinib may be the best treatment for choroidal metastasis in patients harboring an ALK translocation because of its favorable side effect profile involving visual disturbances.
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spelling pubmed-56353062017-10-12 Successful Treatment with Alectinib for Choroidal Metastasis in Anaplastic Lymphoma Kinase Rearranged Non-small Cell Lung Cancer Funazo, Tomoko Morita, Kyohei Ikegami, Naoya Konishi, Chisato Nakao, Satoshi Ariyasu, Ryo Taki, Masato Nakagawa, Kazuhiko Hwang, Moon Hee Yoshimura, Chie Wakayama, Toshiaki Nishizaka, Yasuo Intern Med Case Report Choroidal metastasis is rare in cancer patients and it may cause visual disturbances that reduce their quality of life. In non-small cell lung cancer (NSCLC), targeted therapy against actionable driver mutations has gradually replaced radiotherapy as the treatment of choice for choroidal metastasis. Recently, there have been several case reports of choroidal metastasis in patients with anaplastic lymphoma kinase (ALK)-rearranged NSCLC. We herein report the case of a 40-year-old Japanese woman diagnosed with choroidal metastasis of an ALK-rearranged NSCLC who received alectinib as the first-line chemotherapy. Alectinib may be the best treatment for choroidal metastasis in patients harboring an ALK translocation because of its favorable side effect profile involving visual disturbances. The Japanese Society of Internal Medicine 2017-08-10 2017-09-01 /pmc/articles/PMC5635306/ /pubmed/28794371 http://dx.doi.org/10.2169/internalmedicine.8488-16 Text en Copyright © 2017 by The Japanese Society of Internal Medicine https://creativecommons.org/licenses/by-nc-nd/4.0/ The Internal Medicine is an Open Access article distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License. To view the details of this license, please visit (https://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Case Report
Funazo, Tomoko
Morita, Kyohei
Ikegami, Naoya
Konishi, Chisato
Nakao, Satoshi
Ariyasu, Ryo
Taki, Masato
Nakagawa, Kazuhiko
Hwang, Moon Hee
Yoshimura, Chie
Wakayama, Toshiaki
Nishizaka, Yasuo
Successful Treatment with Alectinib for Choroidal Metastasis in Anaplastic Lymphoma Kinase Rearranged Non-small Cell Lung Cancer
title Successful Treatment with Alectinib for Choroidal Metastasis in Anaplastic Lymphoma Kinase Rearranged Non-small Cell Lung Cancer
title_full Successful Treatment with Alectinib for Choroidal Metastasis in Anaplastic Lymphoma Kinase Rearranged Non-small Cell Lung Cancer
title_fullStr Successful Treatment with Alectinib for Choroidal Metastasis in Anaplastic Lymphoma Kinase Rearranged Non-small Cell Lung Cancer
title_full_unstemmed Successful Treatment with Alectinib for Choroidal Metastasis in Anaplastic Lymphoma Kinase Rearranged Non-small Cell Lung Cancer
title_short Successful Treatment with Alectinib for Choroidal Metastasis in Anaplastic Lymphoma Kinase Rearranged Non-small Cell Lung Cancer
title_sort successful treatment with alectinib for choroidal metastasis in anaplastic lymphoma kinase rearranged non-small cell lung cancer
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5635306/
https://www.ncbi.nlm.nih.gov/pubmed/28794371
http://dx.doi.org/10.2169/internalmedicine.8488-16
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