Plasmablastic Lymphoma: Case Report of Prolonged Survival of an Advanced Human Immunodeficiency Patient and Literature Review

Clinical Practice Points. Plasmablastic lymphoma (PBL) is a rare and highly aggressive variant of diffuse large B cell lymphoma with median survival of advanced stage patients varying between 6 and 15 months in previous reports. We report here a human immunodeficiency virus-infected patient survivin...

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Autores principales: Rafei, Hind, El-Bahesh, Ehab, Finianos, Antoine, Liu, Min-Ling L., Schechter, Geraldine P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2017
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5635466/
https://www.ncbi.nlm.nih.gov/pubmed/29090101
http://dx.doi.org/10.1155/2017/9561013
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author Rafei, Hind
El-Bahesh, Ehab
Finianos, Antoine
Liu, Min-Ling L.
Schechter, Geraldine P.
author_facet Rafei, Hind
El-Bahesh, Ehab
Finianos, Antoine
Liu, Min-Ling L.
Schechter, Geraldine P.
author_sort Rafei, Hind
collection PubMed
description Clinical Practice Points. Plasmablastic lymphoma (PBL) is a rare and highly aggressive variant of diffuse large B cell lymphoma with median survival of advanced stage patients varying between 6 and 15 months in previous reports. We report here a human immunodeficiency virus-infected patient surviving over 12 years following treatment for advanced PBL with EPOCH chemotherapy and intrathecal therapy. This case highlights the potential for improved survival in PBL with intensive chemotherapy. Further, literature review suggests promising prospects utilizing novel targeted therapies to increase the rate of prolonged responses.
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spelling pubmed-56354662017-10-31 Plasmablastic Lymphoma: Case Report of Prolonged Survival of an Advanced Human Immunodeficiency Patient and Literature Review Rafei, Hind El-Bahesh, Ehab Finianos, Antoine Liu, Min-Ling L. Schechter, Geraldine P. Case Rep Hematol Case Report Clinical Practice Points. Plasmablastic lymphoma (PBL) is a rare and highly aggressive variant of diffuse large B cell lymphoma with median survival of advanced stage patients varying between 6 and 15 months in previous reports. We report here a human immunodeficiency virus-infected patient surviving over 12 years following treatment for advanced PBL with EPOCH chemotherapy and intrathecal therapy. This case highlights the potential for improved survival in PBL with intensive chemotherapy. Further, literature review suggests promising prospects utilizing novel targeted therapies to increase the rate of prolonged responses. Hindawi 2017 2017-09-24 /pmc/articles/PMC5635466/ /pubmed/29090101 http://dx.doi.org/10.1155/2017/9561013 Text en Copyright © 2017 Hind Rafei et al. https://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Case Report
Rafei, Hind
El-Bahesh, Ehab
Finianos, Antoine
Liu, Min-Ling L.
Schechter, Geraldine P.
Plasmablastic Lymphoma: Case Report of Prolonged Survival of an Advanced Human Immunodeficiency Patient and Literature Review
title Plasmablastic Lymphoma: Case Report of Prolonged Survival of an Advanced Human Immunodeficiency Patient and Literature Review
title_full Plasmablastic Lymphoma: Case Report of Prolonged Survival of an Advanced Human Immunodeficiency Patient and Literature Review
title_fullStr Plasmablastic Lymphoma: Case Report of Prolonged Survival of an Advanced Human Immunodeficiency Patient and Literature Review
title_full_unstemmed Plasmablastic Lymphoma: Case Report of Prolonged Survival of an Advanced Human Immunodeficiency Patient and Literature Review
title_short Plasmablastic Lymphoma: Case Report of Prolonged Survival of an Advanced Human Immunodeficiency Patient and Literature Review
title_sort plasmablastic lymphoma: case report of prolonged survival of an advanced human immunodeficiency patient and literature review
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5635466/
https://www.ncbi.nlm.nih.gov/pubmed/29090101
http://dx.doi.org/10.1155/2017/9561013
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