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Design, Development, and Optimization of Dexibuprofen Microemulsion Based Transdermal Reservoir Patches for Controlled Drug Delivery

The aim of the study was to develop a reservoir-type transdermal patch for a controlled delivery of dexibuprofen and to evaluate its in vivo anti-inflammatory activity in Albino Wistar rats. In order to develop these patches, six formulations of dexibuprofen microemulsion comprising ethyl oleate, Tw...

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Autores principales: Ali, Fatima Ramzan, Shoaib, Muhammad Harris, Yousuf, Rabia Ismail, Ali, Syed Abid, Imtiaz, Muhammad Suleman, Bashir, Lubna, Naz, Shazia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5635477/
https://www.ncbi.nlm.nih.gov/pubmed/29090219
http://dx.doi.org/10.1155/2017/4654958
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author Ali, Fatima Ramzan
Shoaib, Muhammad Harris
Yousuf, Rabia Ismail
Ali, Syed Abid
Imtiaz, Muhammad Suleman
Bashir, Lubna
Naz, Shazia
author_facet Ali, Fatima Ramzan
Shoaib, Muhammad Harris
Yousuf, Rabia Ismail
Ali, Syed Abid
Imtiaz, Muhammad Suleman
Bashir, Lubna
Naz, Shazia
author_sort Ali, Fatima Ramzan
collection PubMed
description The aim of the study was to develop a reservoir-type transdermal patch for a controlled delivery of dexibuprofen and to evaluate its in vivo anti-inflammatory activity in Albino Wistar rats. In order to develop these patches, six formulations of dexibuprofen microemulsion comprising ethyl oleate, Tween 80: PG (2 : 1), and water were prepared by simplex lattice design and characterized. The reservoir compartment was filled with these microemulsions and in vitro release and skin permeation were assessed. The optimized patch was obtained on the basis of the responses: Q(24) and flux. The impact of drug loading, surface area, membrane thickness, adhesive, and agitation speed on drug release and permeation was also studied. The skin sensitivity reaction and in vivo anti-inflammatory activity of optimized patch were evaluated. Stability study at three different temperatures for three months was carried out. The result suggests that a membrane based patch with zero-order release rate, Q(24) of 79.13 ± 3.08%, and maximum flux of 331.17 µg/cm(2)h can be obtained exhibiting suitable anti-inflammatory activity with no visible skin sensitivity reaction. The outcomes of stability study recommend storage of patches at 4°C having shelf-life of 6.14 months. The study demonstrates that the reservoir-type transdermal patch of dexibuprofen microemulsion has a potential of delivering drug across skin in controlled manner with required anti-inflammatory activity.
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spelling pubmed-56354772017-10-31 Design, Development, and Optimization of Dexibuprofen Microemulsion Based Transdermal Reservoir Patches for Controlled Drug Delivery Ali, Fatima Ramzan Shoaib, Muhammad Harris Yousuf, Rabia Ismail Ali, Syed Abid Imtiaz, Muhammad Suleman Bashir, Lubna Naz, Shazia Biomed Res Int Research Article The aim of the study was to develop a reservoir-type transdermal patch for a controlled delivery of dexibuprofen and to evaluate its in vivo anti-inflammatory activity in Albino Wistar rats. In order to develop these patches, six formulations of dexibuprofen microemulsion comprising ethyl oleate, Tween 80: PG (2 : 1), and water were prepared by simplex lattice design and characterized. The reservoir compartment was filled with these microemulsions and in vitro release and skin permeation were assessed. The optimized patch was obtained on the basis of the responses: Q(24) and flux. The impact of drug loading, surface area, membrane thickness, adhesive, and agitation speed on drug release and permeation was also studied. The skin sensitivity reaction and in vivo anti-inflammatory activity of optimized patch were evaluated. Stability study at three different temperatures for three months was carried out. The result suggests that a membrane based patch with zero-order release rate, Q(24) of 79.13 ± 3.08%, and maximum flux of 331.17 µg/cm(2)h can be obtained exhibiting suitable anti-inflammatory activity with no visible skin sensitivity reaction. The outcomes of stability study recommend storage of patches at 4°C having shelf-life of 6.14 months. The study demonstrates that the reservoir-type transdermal patch of dexibuprofen microemulsion has a potential of delivering drug across skin in controlled manner with required anti-inflammatory activity. Hindawi 2017 2017-09-27 /pmc/articles/PMC5635477/ /pubmed/29090219 http://dx.doi.org/10.1155/2017/4654958 Text en Copyright © 2017 Fatima Ramzan Ali et al. https://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Ali, Fatima Ramzan
Shoaib, Muhammad Harris
Yousuf, Rabia Ismail
Ali, Syed Abid
Imtiaz, Muhammad Suleman
Bashir, Lubna
Naz, Shazia
Design, Development, and Optimization of Dexibuprofen Microemulsion Based Transdermal Reservoir Patches for Controlled Drug Delivery
title Design, Development, and Optimization of Dexibuprofen Microemulsion Based Transdermal Reservoir Patches for Controlled Drug Delivery
title_full Design, Development, and Optimization of Dexibuprofen Microemulsion Based Transdermal Reservoir Patches for Controlled Drug Delivery
title_fullStr Design, Development, and Optimization of Dexibuprofen Microemulsion Based Transdermal Reservoir Patches for Controlled Drug Delivery
title_full_unstemmed Design, Development, and Optimization of Dexibuprofen Microemulsion Based Transdermal Reservoir Patches for Controlled Drug Delivery
title_short Design, Development, and Optimization of Dexibuprofen Microemulsion Based Transdermal Reservoir Patches for Controlled Drug Delivery
title_sort design, development, and optimization of dexibuprofen microemulsion based transdermal reservoir patches for controlled drug delivery
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5635477/
https://www.ncbi.nlm.nih.gov/pubmed/29090219
http://dx.doi.org/10.1155/2017/4654958
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