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Imported malaria in Spain (2009–2016): results from the +REDIVI Collaborative Network

BACKGROUND: Imported malaria is a frequent diagnosis in travellers and migrants. The objective of this study was to describe the epidemiological and clinical characteristics of patients diagnosed with imported malaria within a Spanish collaborative network registering imported diseases (+REDIVI). In...

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Autores principales: Norman, Francesca F., López-Polín, Ana, Salvador, Fernando, Treviño, Begoña, Calabuig, Eva, Torrús, Diego, Soriano-Arandes, Antonio, Ruíz-Giardín, Jose-Manuel, Monge-Maillo, Begoña, Pérez-Molina, Jose-Antonio, Perez-Ayala, Ana, García, Magdalena, Rodríguez, Azucena, Martínez-Serrano, María, Zubero, Miren, López-Vélez, Rogelio
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5635489/
https://www.ncbi.nlm.nih.gov/pubmed/29017499
http://dx.doi.org/10.1186/s12936-017-2057-8
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author Norman, Francesca F.
López-Polín, Ana
Salvador, Fernando
Treviño, Begoña
Calabuig, Eva
Torrús, Diego
Soriano-Arandes, Antonio
Ruíz-Giardín, Jose-Manuel
Monge-Maillo, Begoña
Pérez-Molina, Jose-Antonio
Perez-Ayala, Ana
García, Magdalena
Rodríguez, Azucena
Martínez-Serrano, María
Zubero, Miren
López-Vélez, Rogelio
author_facet Norman, Francesca F.
López-Polín, Ana
Salvador, Fernando
Treviño, Begoña
Calabuig, Eva
Torrús, Diego
Soriano-Arandes, Antonio
Ruíz-Giardín, Jose-Manuel
Monge-Maillo, Begoña
Pérez-Molina, Jose-Antonio
Perez-Ayala, Ana
García, Magdalena
Rodríguez, Azucena
Martínez-Serrano, María
Zubero, Miren
López-Vélez, Rogelio
author_sort Norman, Francesca F.
collection PubMed
description BACKGROUND: Imported malaria is a frequent diagnosis in travellers and migrants. The objective of this study was to describe the epidemiological and clinical characteristics of patients diagnosed with imported malaria within a Spanish collaborative network registering imported diseases (+REDIVI). In addition, the possible association between malaria and type of case, gender, age or area of exposure was explored. METHODS: Cases of imported malaria were identified among all cases registered in the +REDIVI database during the period October 2009–October 2016. Demographic, epidemiological and clinical characteristics were analysed. RESULTS: In total, 11,816 cases of imported infectious diseases were registered in +REDIVI’s database between October 2009 and October 2016. Immigrants seen for the first time after migration accounted for 60.2% of cases, 21.0% of patients were travellers, and 18.8% were travellers/immigrants visiting friends and relatives (VFRs). There were 850 cases of malaria (850/11,816, 7.2%). Malaria was significantly more frequent in men than in women (56.8% vs 43.2%) and in VFR-immigrants (52.6%) as compared to travellers (21.3%), immigrants (20.7%) and VFR-travellers (5.4%) (p < 0.001). Although this data was not available for most patients with malaria, only a minority (29/217, 13.4%) mentioned correct anti-malarial prophylaxis. Sub-Saharan Africa was found to be the most common region of acquisition of malaria. Most common reason for consultation after travel was a febrile syndrome although an important proportion of immigrants were asymptomatic and presented only for health screening (27.3%). Around 5% of travellers presented with severe malaria. The most prevalent species of Plasmodium diagnosed was Plasmodium falciparum (81.5%). Malaria due to Plasmodium ovale/Plasmodium vivax was frequent among travellers (17%) and nearly 5% of all malaria cases in immigrants were caused by Plasmodium malariae. CONCLUSIONS: Malaria was among the five most frequent diagnoses registered in +REDIVI’s database. Some significant differences were found in the distribution of malaria according to gender, type of case, species. Among all malaria cases, the most frequent diagnosis was P. falciparum infection in VFR-immigrant men.
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spelling pubmed-56354892017-10-18 Imported malaria in Spain (2009–2016): results from the +REDIVI Collaborative Network Norman, Francesca F. López-Polín, Ana Salvador, Fernando Treviño, Begoña Calabuig, Eva Torrús, Diego Soriano-Arandes, Antonio Ruíz-Giardín, Jose-Manuel Monge-Maillo, Begoña Pérez-Molina, Jose-Antonio Perez-Ayala, Ana García, Magdalena Rodríguez, Azucena Martínez-Serrano, María Zubero, Miren López-Vélez, Rogelio Malar J Research BACKGROUND: Imported malaria is a frequent diagnosis in travellers and migrants. The objective of this study was to describe the epidemiological and clinical characteristics of patients diagnosed with imported malaria within a Spanish collaborative network registering imported diseases (+REDIVI). In addition, the possible association between malaria and type of case, gender, age or area of exposure was explored. METHODS: Cases of imported malaria were identified among all cases registered in the +REDIVI database during the period October 2009–October 2016. Demographic, epidemiological and clinical characteristics were analysed. RESULTS: In total, 11,816 cases of imported infectious diseases were registered in +REDIVI’s database between October 2009 and October 2016. Immigrants seen for the first time after migration accounted for 60.2% of cases, 21.0% of patients were travellers, and 18.8% were travellers/immigrants visiting friends and relatives (VFRs). There were 850 cases of malaria (850/11,816, 7.2%). Malaria was significantly more frequent in men than in women (56.8% vs 43.2%) and in VFR-immigrants (52.6%) as compared to travellers (21.3%), immigrants (20.7%) and VFR-travellers (5.4%) (p < 0.001). Although this data was not available for most patients with malaria, only a minority (29/217, 13.4%) mentioned correct anti-malarial prophylaxis. Sub-Saharan Africa was found to be the most common region of acquisition of malaria. Most common reason for consultation after travel was a febrile syndrome although an important proportion of immigrants were asymptomatic and presented only for health screening (27.3%). Around 5% of travellers presented with severe malaria. The most prevalent species of Plasmodium diagnosed was Plasmodium falciparum (81.5%). Malaria due to Plasmodium ovale/Plasmodium vivax was frequent among travellers (17%) and nearly 5% of all malaria cases in immigrants were caused by Plasmodium malariae. CONCLUSIONS: Malaria was among the five most frequent diagnoses registered in +REDIVI’s database. Some significant differences were found in the distribution of malaria according to gender, type of case, species. Among all malaria cases, the most frequent diagnosis was P. falciparum infection in VFR-immigrant men. BioMed Central 2017-10-10 /pmc/articles/PMC5635489/ /pubmed/29017499 http://dx.doi.org/10.1186/s12936-017-2057-8 Text en © The Author(s) 2017 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Research
Norman, Francesca F.
López-Polín, Ana
Salvador, Fernando
Treviño, Begoña
Calabuig, Eva
Torrús, Diego
Soriano-Arandes, Antonio
Ruíz-Giardín, Jose-Manuel
Monge-Maillo, Begoña
Pérez-Molina, Jose-Antonio
Perez-Ayala, Ana
García, Magdalena
Rodríguez, Azucena
Martínez-Serrano, María
Zubero, Miren
López-Vélez, Rogelio
Imported malaria in Spain (2009–2016): results from the +REDIVI Collaborative Network
title Imported malaria in Spain (2009–2016): results from the +REDIVI Collaborative Network
title_full Imported malaria in Spain (2009–2016): results from the +REDIVI Collaborative Network
title_fullStr Imported malaria in Spain (2009–2016): results from the +REDIVI Collaborative Network
title_full_unstemmed Imported malaria in Spain (2009–2016): results from the +REDIVI Collaborative Network
title_short Imported malaria in Spain (2009–2016): results from the +REDIVI Collaborative Network
title_sort imported malaria in spain (2009–2016): results from the +redivi collaborative network
topic Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5635489/
https://www.ncbi.nlm.nih.gov/pubmed/29017499
http://dx.doi.org/10.1186/s12936-017-2057-8
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