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Inhibition of (pro)renin Receptor Contributes to Renoprotective Effects of Angiotensin II Type 1 Receptor Blockade in Diabetic Nephropathy

Aims: Renal renin-angiotensin system (RAS) plays a pivotal role in the development of diabetic nephropathy (DN). Angiotensin II (Ang II) type 1 receptor (AT(1)R) blockade elevates (pro)renin, which may bind to (pro)renin receptor (PRR) and exert receptor-mediated, angiotensin-independent profibrotic...

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Detalles Bibliográficos
Autores principales:	Zhang, Lin, An, Xiao-Fei, Ruan, Xin, Huang, Dong-Dong, Zhou, Li, Xue, Hong, Lu, Li-Min, He, Ming
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2017
Materias:	Physiology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5635681/ https://www.ncbi.nlm.nih.gov/pubmed/29056916 http://dx.doi.org/10.3389/fphys.2017.00758

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