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Evaluation of MIh Scoring System in Diagnosis of Obstructive Sleep Apnea Syndrome
BACKGROUND: The objective of the present study was to investigate whether the analysis of magnesium (Mg), high-sensitivity C-reactive protein (hsCRP), and ischemia-modified albumin (IMA) concentrations can be used as a non-invasive and convenient method for diagnosing obstructive sleep apnea syndrom...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
International Scientific Literature, Inc.
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5635950/ https://www.ncbi.nlm.nih.gov/pubmed/28966342 http://dx.doi.org/10.12659/MSM.904087 |
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author | Xu, Qinxing Du, Junwei Ling, Xiaobo Lu, Yangfei |
author_facet | Xu, Qinxing Du, Junwei Ling, Xiaobo Lu, Yangfei |
author_sort | Xu, Qinxing |
collection | PubMed |
description | BACKGROUND: The objective of the present study was to investigate whether the analysis of magnesium (Mg), high-sensitivity C-reactive protein (hsCRP), and ischemia-modified albumin (IMA) concentrations can be used as a non-invasive and convenient method for diagnosing obstructive sleep apnea syndrome (OSAS). MATERIAL/METHODS: After polysomnography, venous blood was collected from 33 patients with OSAS and 30 control individuals. Serum levels of Mg, hsCRP, and IMA were investigated. The relationship between these factors and apnea–hypopnea index (AHI) was analyzed using the Pearson correlation coefficient. The role of the factors was determined using a receiver operating characteristic (ROC) curve and multivariate logistic regression analysis. RESULTS: The levels of hsCRP and IMA were significantly higher in patients with OSAS than in control subjects, while the levels of Mg were lower (P<0.05 for all). A significant correlation was noted between serum IMA (r=0.614; P<0.001) and hsCRP (r=0.453; P<0.001) levels and the AHI. The ROC showed that serum Mg (AUC=0.74(0.62–0.85)), hsCRP (AUC=0.77(0.65–0.87)), and IMA (AUC=0.78(0.66–0.87)) levels could be used as markers to diagnose OSAS. Moreover, our new model, MIh, which is obtained by multivariate analysis, yielded an AUC value of 0.93 (0.83–0.98). Continuous positive airway pressure (CPAP) treatment reversed the changes in the serum levels of Mg, hsCRP, and IMA. CONCLUSIONS: Patients with OSAS show reduced serum Mg levels and elevated serum hsCRP and IMA levels. These observed alterations can be reversed by CPAP treatment. A novel model, named MIh, may be a promising tool for OSAS diagnosis. |
format | Online Article Text |
id | pubmed-5635950 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | International Scientific Literature, Inc. |
record_format | MEDLINE/PubMed |
spelling | pubmed-56359502017-10-26 Evaluation of MIh Scoring System in Diagnosis of Obstructive Sleep Apnea Syndrome Xu, Qinxing Du, Junwei Ling, Xiaobo Lu, Yangfei Med Sci Monit Clinical Research BACKGROUND: The objective of the present study was to investigate whether the analysis of magnesium (Mg), high-sensitivity C-reactive protein (hsCRP), and ischemia-modified albumin (IMA) concentrations can be used as a non-invasive and convenient method for diagnosing obstructive sleep apnea syndrome (OSAS). MATERIAL/METHODS: After polysomnography, venous blood was collected from 33 patients with OSAS and 30 control individuals. Serum levels of Mg, hsCRP, and IMA were investigated. The relationship between these factors and apnea–hypopnea index (AHI) was analyzed using the Pearson correlation coefficient. The role of the factors was determined using a receiver operating characteristic (ROC) curve and multivariate logistic regression analysis. RESULTS: The levels of hsCRP and IMA were significantly higher in patients with OSAS than in control subjects, while the levels of Mg were lower (P<0.05 for all). A significant correlation was noted between serum IMA (r=0.614; P<0.001) and hsCRP (r=0.453; P<0.001) levels and the AHI. The ROC showed that serum Mg (AUC=0.74(0.62–0.85)), hsCRP (AUC=0.77(0.65–0.87)), and IMA (AUC=0.78(0.66–0.87)) levels could be used as markers to diagnose OSAS. Moreover, our new model, MIh, which is obtained by multivariate analysis, yielded an AUC value of 0.93 (0.83–0.98). Continuous positive airway pressure (CPAP) treatment reversed the changes in the serum levels of Mg, hsCRP, and IMA. CONCLUSIONS: Patients with OSAS show reduced serum Mg levels and elevated serum hsCRP and IMA levels. These observed alterations can be reversed by CPAP treatment. A novel model, named MIh, may be a promising tool for OSAS diagnosis. International Scientific Literature, Inc. 2017-10-02 /pmc/articles/PMC5635950/ /pubmed/28966342 http://dx.doi.org/10.12659/MSM.904087 Text en © Med Sci Monit, 2017 This work is licensed under Creative Common Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0 (https://creativecommons.org/licenses/by-nc-nd/4.0/) ) |
spellingShingle | Clinical Research Xu, Qinxing Du, Junwei Ling, Xiaobo Lu, Yangfei Evaluation of MIh Scoring System in Diagnosis of Obstructive Sleep Apnea Syndrome |
title | Evaluation of MIh Scoring System in Diagnosis of Obstructive Sleep Apnea Syndrome |
title_full | Evaluation of MIh Scoring System in Diagnosis of Obstructive Sleep Apnea Syndrome |
title_fullStr | Evaluation of MIh Scoring System in Diagnosis of Obstructive Sleep Apnea Syndrome |
title_full_unstemmed | Evaluation of MIh Scoring System in Diagnosis of Obstructive Sleep Apnea Syndrome |
title_short | Evaluation of MIh Scoring System in Diagnosis of Obstructive Sleep Apnea Syndrome |
title_sort | evaluation of mih scoring system in diagnosis of obstructive sleep apnea syndrome |
topic | Clinical Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5635950/ https://www.ncbi.nlm.nih.gov/pubmed/28966342 http://dx.doi.org/10.12659/MSM.904087 |
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