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Titanium addition influences antibacterial activity of bioactive glass coatings on metallic implants

In an attempt to combat the possibility of bacterial infection and insufficient bone growth around metallic, surgical implants, bioactive glasses may be employed as coatings. In this work, silica-based and borate-based glass series were synthesized for this purpose and subsequently characterized in...

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Autores principales: Rodriguez, Omar, Stone, Wendy, Schemitsch, Emil H., Zalzal, Paul, Waldman, Stephen, Papini, Marcello, Towler, Mark R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5635952/
https://www.ncbi.nlm.nih.gov/pubmed/29034340
http://dx.doi.org/10.1016/j.heliyon.2017.e00420
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author Rodriguez, Omar
Stone, Wendy
Schemitsch, Emil H.
Zalzal, Paul
Waldman, Stephen
Papini, Marcello
Towler, Mark R.
author_facet Rodriguez, Omar
Stone, Wendy
Schemitsch, Emil H.
Zalzal, Paul
Waldman, Stephen
Papini, Marcello
Towler, Mark R.
author_sort Rodriguez, Omar
collection PubMed
description In an attempt to combat the possibility of bacterial infection and insufficient bone growth around metallic, surgical implants, bioactive glasses may be employed as coatings. In this work, silica-based and borate-based glass series were synthesized for this purpose and subsequently characterized in terms of antibacterial behavior, solubility and cytotoxicity. Borate-based glasses were found to exhibit significantly superior antibacterial properties and increased solubility compared to their silica-based counterparts, with BRT0 and BRT3 (borate-based glasses with 0 and 15 mol% of titanium dioxide incorporated, respectively) outperforming the remainder of the glasses, both borate and silicate based, in these respects. Atomic Absorption Spectroscopy confirmed the release of zinc ions (Zn(2+)), which has been linked to the antibacterial abilities of glasses SRT0, BRT0 and BRT3, with inhibition effectively achieved at concentrations lower than 0.7 ppm. In vitro cytotoxicity studies using MC3T3-E1 osteoblasts confirmed that cell proliferation was affected by all glasses in this study, with decreased proliferation attributed to a faster release of sodium ions over calcium ions in both glass series, factor known to slow cell proliferation in vitro.
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spelling pubmed-56359522017-10-13 Titanium addition influences antibacterial activity of bioactive glass coatings on metallic implants Rodriguez, Omar Stone, Wendy Schemitsch, Emil H. Zalzal, Paul Waldman, Stephen Papini, Marcello Towler, Mark R. Heliyon Article In an attempt to combat the possibility of bacterial infection and insufficient bone growth around metallic, surgical implants, bioactive glasses may be employed as coatings. In this work, silica-based and borate-based glass series were synthesized for this purpose and subsequently characterized in terms of antibacterial behavior, solubility and cytotoxicity. Borate-based glasses were found to exhibit significantly superior antibacterial properties and increased solubility compared to their silica-based counterparts, with BRT0 and BRT3 (borate-based glasses with 0 and 15 mol% of titanium dioxide incorporated, respectively) outperforming the remainder of the glasses, both borate and silicate based, in these respects. Atomic Absorption Spectroscopy confirmed the release of zinc ions (Zn(2+)), which has been linked to the antibacterial abilities of glasses SRT0, BRT0 and BRT3, with inhibition effectively achieved at concentrations lower than 0.7 ppm. In vitro cytotoxicity studies using MC3T3-E1 osteoblasts confirmed that cell proliferation was affected by all glasses in this study, with decreased proliferation attributed to a faster release of sodium ions over calcium ions in both glass series, factor known to slow cell proliferation in vitro. Elsevier 2017-10-10 /pmc/articles/PMC5635952/ /pubmed/29034340 http://dx.doi.org/10.1016/j.heliyon.2017.e00420 Text en © 2017 The Authors http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Article
Rodriguez, Omar
Stone, Wendy
Schemitsch, Emil H.
Zalzal, Paul
Waldman, Stephen
Papini, Marcello
Towler, Mark R.
Titanium addition influences antibacterial activity of bioactive glass coatings on metallic implants
title Titanium addition influences antibacterial activity of bioactive glass coatings on metallic implants
title_full Titanium addition influences antibacterial activity of bioactive glass coatings on metallic implants
title_fullStr Titanium addition influences antibacterial activity of bioactive glass coatings on metallic implants
title_full_unstemmed Titanium addition influences antibacterial activity of bioactive glass coatings on metallic implants
title_short Titanium addition influences antibacterial activity of bioactive glass coatings on metallic implants
title_sort titanium addition influences antibacterial activity of bioactive glass coatings on metallic implants
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5635952/
https://www.ncbi.nlm.nih.gov/pubmed/29034340
http://dx.doi.org/10.1016/j.heliyon.2017.e00420
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