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Change of sleep quality from pre- to 3 years post-solid organ transplantation: The Swiss Transplant Cohort Study

BACKGROUND: Poor sleep quality (SQ) is common after solid organ transplantation; however, very little is known about its natural history. We assessed the changes in SQ from pre- to 3 years post-transplant in adult heart, kidney, liver and lung recipients included in the prospective nation-wide Swiss...

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Autores principales: Burkhalter, Hanna, Denhaerynck, Kris, Huynh-Do, Uyen, Binet, Isabelle, Hadaya, Karine, De Geest, Sabina
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5636098/
https://www.ncbi.nlm.nih.gov/pubmed/29020112
http://dx.doi.org/10.1371/journal.pone.0185036
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author Burkhalter, Hanna
Denhaerynck, Kris
Huynh-Do, Uyen
Binet, Isabelle
Hadaya, Karine
De Geest, Sabina
author_facet Burkhalter, Hanna
Denhaerynck, Kris
Huynh-Do, Uyen
Binet, Isabelle
Hadaya, Karine
De Geest, Sabina
author_sort Burkhalter, Hanna
collection PubMed
description BACKGROUND: Poor sleep quality (SQ) is common after solid organ transplantation; however, very little is known about its natural history. We assessed the changes in SQ from pre- to 3 years post-transplant in adult heart, kidney, liver and lung recipients included in the prospective nation-wide Swiss Transplant Cohort Study. We explored associations with selected variables in patients suffering persistent poor SQ compared to those with good or variable SQ. METHODS: Adult single organ transplant recipients enrolled in the Swiss Transplant Cohort Study with pre-transplant and at least 3 post-transplant SQ assessment data were included. SQ was self-reported pre-transplant (at listing), then at 6, 12, 24 and 36 months post-transplant. A single SQ item was used to identify poor (0–5) and good sleepers (6–10). Between organ groups, SQ was compared via logistic regression analysis with generalized estimating equations. Within the group reporting persistently poor SQ, we used logistic regression or Kaplan-Meier analysis as appropriate to check for differences in global quality of life and survival. RESULTS: In a sample of 1173 transplant patients (age: 52.1±13.2 years; 65% males; 66% kidney, 17% liver, 10% lung, 7% heart) transplanted between 2008 and 2012, pre- transplant poor SQ was highest in liver (50%) and heart (49%) recipients. Overall, poor SQ decreased significantly from pre-transplant (38%) to 24 months post-transplant (26%) and remained stable at 3 years (29%). Patients reporting persistently poor SQ had significantly more depressive symptomatology and lower global quality of life. CONCLUSION: Because self-reported poor SQ is related to poorer global quality of life, these results emphasize the need for further studies to find suitable treatment options for poor SQ in transplant recipients.
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spelling pubmed-56360982017-10-30 Change of sleep quality from pre- to 3 years post-solid organ transplantation: The Swiss Transplant Cohort Study Burkhalter, Hanna Denhaerynck, Kris Huynh-Do, Uyen Binet, Isabelle Hadaya, Karine De Geest, Sabina PLoS One Research Article BACKGROUND: Poor sleep quality (SQ) is common after solid organ transplantation; however, very little is known about its natural history. We assessed the changes in SQ from pre- to 3 years post-transplant in adult heart, kidney, liver and lung recipients included in the prospective nation-wide Swiss Transplant Cohort Study. We explored associations with selected variables in patients suffering persistent poor SQ compared to those with good or variable SQ. METHODS: Adult single organ transplant recipients enrolled in the Swiss Transplant Cohort Study with pre-transplant and at least 3 post-transplant SQ assessment data were included. SQ was self-reported pre-transplant (at listing), then at 6, 12, 24 and 36 months post-transplant. A single SQ item was used to identify poor (0–5) and good sleepers (6–10). Between organ groups, SQ was compared via logistic regression analysis with generalized estimating equations. Within the group reporting persistently poor SQ, we used logistic regression or Kaplan-Meier analysis as appropriate to check for differences in global quality of life and survival. RESULTS: In a sample of 1173 transplant patients (age: 52.1±13.2 years; 65% males; 66% kidney, 17% liver, 10% lung, 7% heart) transplanted between 2008 and 2012, pre- transplant poor SQ was highest in liver (50%) and heart (49%) recipients. Overall, poor SQ decreased significantly from pre-transplant (38%) to 24 months post-transplant (26%) and remained stable at 3 years (29%). Patients reporting persistently poor SQ had significantly more depressive symptomatology and lower global quality of life. CONCLUSION: Because self-reported poor SQ is related to poorer global quality of life, these results emphasize the need for further studies to find suitable treatment options for poor SQ in transplant recipients. Public Library of Science 2017-10-11 /pmc/articles/PMC5636098/ /pubmed/29020112 http://dx.doi.org/10.1371/journal.pone.0185036 Text en © 2017 Burkhalter et al http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Research Article
Burkhalter, Hanna
Denhaerynck, Kris
Huynh-Do, Uyen
Binet, Isabelle
Hadaya, Karine
De Geest, Sabina
Change of sleep quality from pre- to 3 years post-solid organ transplantation: The Swiss Transplant Cohort Study
title Change of sleep quality from pre- to 3 years post-solid organ transplantation: The Swiss Transplant Cohort Study
title_full Change of sleep quality from pre- to 3 years post-solid organ transplantation: The Swiss Transplant Cohort Study
title_fullStr Change of sleep quality from pre- to 3 years post-solid organ transplantation: The Swiss Transplant Cohort Study
title_full_unstemmed Change of sleep quality from pre- to 3 years post-solid organ transplantation: The Swiss Transplant Cohort Study
title_short Change of sleep quality from pre- to 3 years post-solid organ transplantation: The Swiss Transplant Cohort Study
title_sort change of sleep quality from pre- to 3 years post-solid organ transplantation: the swiss transplant cohort study
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5636098/
https://www.ncbi.nlm.nih.gov/pubmed/29020112
http://dx.doi.org/10.1371/journal.pone.0185036
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