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The N-terminal domains of FLASH and Lsm11 form a 2:1 heterotrimer for histone pre-mRNA 3’-end processing
Unlike canonical pre-mRNAs, animal replication-dependent histone pre-mRNAs lack introns and are processed at the 3’-end by a mechanism distinct from cleavage and polyadenylation. They have a 3’ stem loop and histone downstream element (HDE) that are recognized by stem-loop binding protein (SLBP) and...
Autores principales: | Aik, Wei Shen, Lin, Min-Han, Tan, Dazhi, Tripathy, Ashutosh, Marzluff, William F., Dominski, Zbigniew, Chou, Chi-Yuan, Tong, Liang |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5636114/ https://www.ncbi.nlm.nih.gov/pubmed/29020104 http://dx.doi.org/10.1371/journal.pone.0186034 |
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