Expression level of human TLR4 rather than sequence is the key determinant of LPS responsiveness

To address the role of Toll-like receptor 4 (TLR4) single nucleotide polymorphisms (SNP) in lipopolysaccharide (LPS) recognition, we generated mice that differed only in the sequence of TLR4. We used a bacterial artificial chromosome (BAC) transgenic approach and TLR4/MD-2 knockout mice to specifica...

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Detalles Bibliográficos
Autores principales: Hajjar, Adeline M., Ernst, Robert K., Yi, Jaehun, Yam, Cathy S., Miller, Samuel I.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2017
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5636155/
https://www.ncbi.nlm.nih.gov/pubmed/29020088
http://dx.doi.org/10.1371/journal.pone.0186308

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5636155/
https://www.ncbi.nlm.nih.gov/pubmed/29020088
http://dx.doi.org/10.1371/journal.pone.0186308

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