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Targeting miR-423-5p Reverses Exercise Training–Induced HCN4 Channel Remodeling and Sinus Bradycardia

RATIONALE: Downregulation of the pacemaking ion channel, HCN4 (hyperpolarization-activated cyclic nucleotide gated channel 4), and the corresponding ionic current, I(f), underlies exercise training–induced sinus bradycardia in rodents. If this occurs in humans, it could explain the increased inciden...

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Detalles Bibliográficos
Autores principales:	D’Souza, Alicia, Pearman, Charles M., Wang, Yanwen, Nakao, Shu, Logantha, Sunil Jit R.J., Cox, Charlotte, Bennett, Hayley, Zhang, Yu, Johnsen, Anne Berit, Linscheid, Nora, Poulsen, Pi Camilla, Elliott, Jonathan, Coulson, Jessica, McPhee, Jamie, Robertson, Abigail, da Costa Martins, Paula A., Kitmitto, Ashraf, Wisløff, Ulrik, Cartwright, Elizabeth J., Monfredi, Oliver, Lundby, Alicia, Dobrzynski, Halina, Oceandy, Delvac, Morris, Gwilym M., Boyett, Mark R.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Lippincott Williams & Wilkins 2017
Materias:	Molecular Medicine
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5636198/ https://www.ncbi.nlm.nih.gov/pubmed/28821541 http://dx.doi.org/10.1161/CIRCRESAHA.117.311607

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