Dnmt3a Regulates T-cell Development and Suppresses T-ALL Transformation

T-cell acute lymphoblastic leukemia (T-ALL) is an aggressive hematopoietic neoplasm resulting from the malignant transformation of T-cell progenitors, and comprises approximately 15% and 25% of pediatric and adult ALL cases respectively. It is well-established that activating NOTCH1 mutations are th...

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Detalles Bibliográficos
Autores principales: Kramer, Ashley C., Kothari, Alok, Wilson, W. Casey, Celik, Hamza, Nikitas, John, Mallaney, Cates, Ostrander, Elizabeth L., Eultgen, Elizabeth, Martens, Andrew, Valentine, Mark C., Young, Andrew L., Druley, Todd E., Figueroa, Maria E., Zhang, Bo, Challen, Grant A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5636646/
https://www.ncbi.nlm.nih.gov/pubmed/28321121
http://dx.doi.org/10.1038/leu.2017.89

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