A key role for peroxynitrite-mediated inhibition of cardiac ERG (Kv11.1) K(+) channels in carbon monoxide–induced proarrhythmic early afterdepolarizations

Exposure to CO causes early afterdepolarization arrhythmias. Previous studies in rats have indicated that arrhythmias arose as a result of augmentation of the late Na(+) current. The purpose of the present study was to examine the basis for CO-induced arrhythmias in guinea pig myocytes in which acti...

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Detalles Bibliográficos
Autores principales: Al-Owais, Moza M., Hettiarachchi, Nishani T., Kirton, Hannah M., Hardy, Matthew E., Boyle, John P., Scragg, Jason L., Steele, Derek S., Peers, Chris
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Federation of American Societies for Experimental Biology 2017
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5636698/
https://www.ncbi.nlm.nih.gov/pubmed/28743763
http://dx.doi.org/10.1096/fj.201700259R

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