Role of Recepteur D'origine Nantais on Gastric Cancer Development and Progression

Recepteur d'origine nantais (RON) is a receptor tyrosine kinase belonging to the subfamily of which c-MET is the prototype. Large epidemiologic studies have confirmed the strong association between RON and gastric cancer development. Constitutive activation of RON signaling directly correlates...

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Detalles Bibliográficos
Autores principales: Yang, Sung Yeul, Nguyen, Thi Thinh, Ung, Trong Thuan, Jung, Young Do
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Chonnam National University Medical School 2017
Materias:
Review Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5636756/
https://www.ncbi.nlm.nih.gov/pubmed/29026705
http://dx.doi.org/10.4068/cmj.2017.53.3.178
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author Yang, Sung Yeul
Nguyen, Thi Thinh
Ung, Trong Thuan
Jung, Young Do
author_facet Yang, Sung Yeul
Nguyen, Thi Thinh
Ung, Trong Thuan
Jung, Young Do
author_sort Yang, Sung Yeul
collection PubMed
description Recepteur d'origine nantais (RON) is a receptor tyrosine kinase belonging to the subfamily of which c-MET is the prototype. Large epidemiologic studies have confirmed the strong association between RON and gastric cancer development. Constitutive activation of RON signaling directly correlates with tumorigenic phenotypes of gastric cancer and a poor survival rate in advanced gastric cancer patients. In this review, we focus on recent evidence of the aberrant expression and activation of RON in gastric cancer tumors and provide insights into the mechanism of RON signaling associated with gastric cancer progression and metastasis. Current therapeutics against RON in gastric cancer are summarized.
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spelling pubmed-56367562017-10-12 Role of Recepteur D'origine Nantais on Gastric Cancer Development and Progression Yang, Sung Yeul Nguyen, Thi Thinh Ung, Trong Thuan Jung, Young Do Chonnam Med J Review Article Recepteur d'origine nantais (RON) is a receptor tyrosine kinase belonging to the subfamily of which c-MET is the prototype. Large epidemiologic studies have confirmed the strong association between RON and gastric cancer development. Constitutive activation of RON signaling directly correlates with tumorigenic phenotypes of gastric cancer and a poor survival rate in advanced gastric cancer patients. In this review, we focus on recent evidence of the aberrant expression and activation of RON in gastric cancer tumors and provide insights into the mechanism of RON signaling associated with gastric cancer progression and metastasis. Current therapeutics against RON in gastric cancer are summarized. Chonnam National University Medical School 2017-09 2017-09-25 /pmc/articles/PMC5636756/ /pubmed/29026705 http://dx.doi.org/10.4068/cmj.2017.53.3.178 Text en © Chonnam Medical Journal, 2017 http://creativecommons.org/licenses/by-nc/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Yang, Sung Yeul
Nguyen, Thi Thinh
Ung, Trong Thuan
Jung, Young Do
Role of Recepteur D'origine Nantais on Gastric Cancer Development and Progression
title Role of Recepteur D'origine Nantais on Gastric Cancer Development and Progression
title_full Role of Recepteur D'origine Nantais on Gastric Cancer Development and Progression
title_fullStr Role of Recepteur D'origine Nantais on Gastric Cancer Development and Progression
title_full_unstemmed Role of Recepteur D'origine Nantais on Gastric Cancer Development and Progression
title_short Role of Recepteur D'origine Nantais on Gastric Cancer Development and Progression
title_sort role of recepteur d'origine nantais on gastric cancer development and progression
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5636756/
https://www.ncbi.nlm.nih.gov/pubmed/29026705
http://dx.doi.org/10.4068/cmj.2017.53.3.178
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