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Glycated Hemoglobin and All-Cause Mortality in Korean Type 2 Diabetes
The purpose of this study was to evaluate the association between glycated hemoglobin (HbA1c) and all-cause mortality in type 2 diabetes mellitus. We conducted a community-based prospective cohort study of 352 type 2 diabetic patients aged 30-92 who participated in a community diabetes complications...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Chonnam National University Medical School
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5636762/ https://www.ncbi.nlm.nih.gov/pubmed/29026711 http://dx.doi.org/10.4068/cmj.2017.53.3.223 |
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author | An, Mi Suk Kim, Sun A Lee, Jun-Ho Choi, Seong-Woo Shin, Min-Ho |
author_facet | An, Mi Suk Kim, Sun A Lee, Jun-Ho Choi, Seong-Woo Shin, Min-Ho |
author_sort | An, Mi Suk |
collection | PubMed |
description | The purpose of this study was to evaluate the association between glycated hemoglobin (HbA1c) and all-cause mortality in type 2 diabetes mellitus. We conducted a community-based prospective cohort study of 352 type 2 diabetic patients aged 30-92 who participated in a community diabetes complications screening program in Gokseng-gun, Jeollanamdo, Korea. HbA1c levels were categorized as <6.5%, 6.5-6.9%, 7.0-7.9%, 8.0-8.9% and ≥9.0%. Patients were followed up on for a mean of 6.9 years. The Cox proportional hazards model was used to evaluate the relationship between HbA1c levels and all-cause mortality. During the mean follow-up period of 6.9 years, 77 patients (21.9%) died. A J-shaped association was found between HbA1c and all-cause mortality, with the lowest mortality at 6.5-6.9% of HbA1c levels. Compared to patients with HbA1c of 6.5-6.9%, patients with <6.5%, 7.0-7.9%, 8.0-8.9% and ≥9.0% had an adjusted hazard ratio (95% confidence interval) for all-cause mortality of 1.71 (0.76-3.84), 1.23 (0.53-2.82), 1.32(0.51-3.44) and 2.66 (1.01-7.02), respectively. We found a J-shaped association between glycated hemoglobin and all-cause mortality in Korean type 2 diabetic patients. |
format | Online Article Text |
id | pubmed-5636762 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | Chonnam National University Medical School |
record_format | MEDLINE/PubMed |
spelling | pubmed-56367622017-10-12 Glycated Hemoglobin and All-Cause Mortality in Korean Type 2 Diabetes An, Mi Suk Kim, Sun A Lee, Jun-Ho Choi, Seong-Woo Shin, Min-Ho Chonnam Med J Original Article The purpose of this study was to evaluate the association between glycated hemoglobin (HbA1c) and all-cause mortality in type 2 diabetes mellitus. We conducted a community-based prospective cohort study of 352 type 2 diabetic patients aged 30-92 who participated in a community diabetes complications screening program in Gokseng-gun, Jeollanamdo, Korea. HbA1c levels were categorized as <6.5%, 6.5-6.9%, 7.0-7.9%, 8.0-8.9% and ≥9.0%. Patients were followed up on for a mean of 6.9 years. The Cox proportional hazards model was used to evaluate the relationship between HbA1c levels and all-cause mortality. During the mean follow-up period of 6.9 years, 77 patients (21.9%) died. A J-shaped association was found between HbA1c and all-cause mortality, with the lowest mortality at 6.5-6.9% of HbA1c levels. Compared to patients with HbA1c of 6.5-6.9%, patients with <6.5%, 7.0-7.9%, 8.0-8.9% and ≥9.0% had an adjusted hazard ratio (95% confidence interval) for all-cause mortality of 1.71 (0.76-3.84), 1.23 (0.53-2.82), 1.32(0.51-3.44) and 2.66 (1.01-7.02), respectively. We found a J-shaped association between glycated hemoglobin and all-cause mortality in Korean type 2 diabetic patients. Chonnam National University Medical School 2017-09 2017-09-25 /pmc/articles/PMC5636762/ /pubmed/29026711 http://dx.doi.org/10.4068/cmj.2017.53.3.223 Text en © Chonnam Medical Journal, 2017 http://creativecommons.org/licenses/by-nc/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Original Article An, Mi Suk Kim, Sun A Lee, Jun-Ho Choi, Seong-Woo Shin, Min-Ho Glycated Hemoglobin and All-Cause Mortality in Korean Type 2 Diabetes |
title | Glycated Hemoglobin and All-Cause Mortality in Korean Type 2 Diabetes |
title_full | Glycated Hemoglobin and All-Cause Mortality in Korean Type 2 Diabetes |
title_fullStr | Glycated Hemoglobin and All-Cause Mortality in Korean Type 2 Diabetes |
title_full_unstemmed | Glycated Hemoglobin and All-Cause Mortality in Korean Type 2 Diabetes |
title_short | Glycated Hemoglobin and All-Cause Mortality in Korean Type 2 Diabetes |
title_sort | glycated hemoglobin and all-cause mortality in korean type 2 diabetes |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5636762/ https://www.ncbi.nlm.nih.gov/pubmed/29026711 http://dx.doi.org/10.4068/cmj.2017.53.3.223 |
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