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Characterization of the metallo-dependent amidohydrolases responsible for “auxiliary” leucinyl removal in the biosynthesis of 2,2′-bipyridine antibiotics

2,2′-Bipyridine (2,2′-BiPy) is an attractive core structure present in a number of biologically active natural products, including the structurally related antibiotics caerulomycins (CAEs) and collismycins (COLs). Their biosynthetic pathways share a similar key 2,2′-BiPy-l-leucine intermediate, whic...

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Detalles Bibliográficos
Autores principales:	Chen, Ming, Pang, Bo, Du, Ya-nan, Zhang, Yi-peng, Liu, Wen
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	KeAi Publishing 2017
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5636949/ https://www.ncbi.nlm.nih.gov/pubmed/29062971 http://dx.doi.org/10.1016/j.synbio.2017.07.002

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