Disrupting CCT-β : β-tubulin selectively kills CCT-β overexpressed cancer cells through MAPKs activation

We have previously demonstrated the ability of I-Trp to disrupt the protein–protein interaction of β-tubulin with chaperonin-containing TCP-1β (CCT-β). This caused more severe apoptosis in multidrug-resistant MES-SA/Dx5, compared to MES-SA, due to its higher CCT-β overexpression. In this study, we s...

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Detalles Bibliográficos
Autores principales: Liu, Yan-Jin, Kumar, Vathan, Lin, Yuan-Feng, Liang, Po-Huang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2017
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5636972/
https://www.ncbi.nlm.nih.gov/pubmed/28906489
http://dx.doi.org/10.1038/cddis.2017.425

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5636972/
https://www.ncbi.nlm.nih.gov/pubmed/28906489
http://dx.doi.org/10.1038/cddis.2017.425

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