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Progression from an Inflammatory to a Fibrostenotic Phenotype in Eosinophilic Esophagitis

Previous studies have suggested that eosinophilic esophagitis (EoE) progresses from chronic inflammation to fibrostenosis. However, natural history data illustrating this progression in individual patients are lacking. Here, we present 6 patients who progressed from an inflammatory to a fibrostenoti...

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Detalles Bibliográficos
Autores principales: Koutlas, Nathaniel T., Dellon, Evan S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: S. Karger AG 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5637006/
https://www.ncbi.nlm.nih.gov/pubmed/29033756
http://dx.doi.org/10.1159/000477391
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author Koutlas, Nathaniel T.
Dellon, Evan S.
author_facet Koutlas, Nathaniel T.
Dellon, Evan S.
author_sort Koutlas, Nathaniel T.
collection PubMed
description Previous studies have suggested that eosinophilic esophagitis (EoE) progresses from chronic inflammation to fibrostenosis. However, natural history data illustrating this progression in individual patients are lacking. Here, we present 6 patients who progressed from an inflammatory to a fibrostenotic phenotype of EoE in the absence of treatment. At the time of diagnosis, none of the patients had significant evidence of fibrostenosis, but they did have other inflammatory findings of EoE such as edema, linear furrows, or exudates. After being lost to follow-up and treatment for an average of 7.8 ± 2.0 years, strictures (n = 5; 83%) or a small-caliber esophagus (n = 4; 67%) were present in a majority of the patients, and the majority required esophageal dilation. These cases confirm that EoE can progress from an inflammation-only phenotype to a fibrostenotic phenotype in certain patients.
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spelling pubmed-56370062017-10-13 Progression from an Inflammatory to a Fibrostenotic Phenotype in Eosinophilic Esophagitis Koutlas, Nathaniel T. Dellon, Evan S. Case Rep Gastroenterol Case Series Previous studies have suggested that eosinophilic esophagitis (EoE) progresses from chronic inflammation to fibrostenosis. However, natural history data illustrating this progression in individual patients are lacking. Here, we present 6 patients who progressed from an inflammatory to a fibrostenotic phenotype of EoE in the absence of treatment. At the time of diagnosis, none of the patients had significant evidence of fibrostenosis, but they did have other inflammatory findings of EoE such as edema, linear furrows, or exudates. After being lost to follow-up and treatment for an average of 7.8 ± 2.0 years, strictures (n = 5; 83%) or a small-caliber esophagus (n = 4; 67%) were present in a majority of the patients, and the majority required esophageal dilation. These cases confirm that EoE can progress from an inflammation-only phenotype to a fibrostenotic phenotype in certain patients. S. Karger AG 2017-06-15 /pmc/articles/PMC5637006/ /pubmed/29033756 http://dx.doi.org/10.1159/000477391 Text en Copyright © 2017 by S. Karger AG, Basel http://creativecommons.org/licenses/by-nc/4.0/ This article is licensed under the Creative Commons Attribution-NonCommercial-4.0 International License (CC BY-NC) (http://www.karger.com/Services/OpenAccessLicense). Usage and distribution for commercial purposes requires written permission.
spellingShingle Case Series
Koutlas, Nathaniel T.
Dellon, Evan S.
Progression from an Inflammatory to a Fibrostenotic Phenotype in Eosinophilic Esophagitis
title Progression from an Inflammatory to a Fibrostenotic Phenotype in Eosinophilic Esophagitis
title_full Progression from an Inflammatory to a Fibrostenotic Phenotype in Eosinophilic Esophagitis
title_fullStr Progression from an Inflammatory to a Fibrostenotic Phenotype in Eosinophilic Esophagitis
title_full_unstemmed Progression from an Inflammatory to a Fibrostenotic Phenotype in Eosinophilic Esophagitis
title_short Progression from an Inflammatory to a Fibrostenotic Phenotype in Eosinophilic Esophagitis
title_sort progression from an inflammatory to a fibrostenotic phenotype in eosinophilic esophagitis
topic Case Series
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5637006/
https://www.ncbi.nlm.nih.gov/pubmed/29033756
http://dx.doi.org/10.1159/000477391
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