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Progression from an Inflammatory to a Fibrostenotic Phenotype in Eosinophilic Esophagitis
Previous studies have suggested that eosinophilic esophagitis (EoE) progresses from chronic inflammation to fibrostenosis. However, natural history data illustrating this progression in individual patients are lacking. Here, we present 6 patients who progressed from an inflammatory to a fibrostenoti...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
S. Karger AG
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5637006/ https://www.ncbi.nlm.nih.gov/pubmed/29033756 http://dx.doi.org/10.1159/000477391 |
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author | Koutlas, Nathaniel T. Dellon, Evan S. |
author_facet | Koutlas, Nathaniel T. Dellon, Evan S. |
author_sort | Koutlas, Nathaniel T. |
collection | PubMed |
description | Previous studies have suggested that eosinophilic esophagitis (EoE) progresses from chronic inflammation to fibrostenosis. However, natural history data illustrating this progression in individual patients are lacking. Here, we present 6 patients who progressed from an inflammatory to a fibrostenotic phenotype of EoE in the absence of treatment. At the time of diagnosis, none of the patients had significant evidence of fibrostenosis, but they did have other inflammatory findings of EoE such as edema, linear furrows, or exudates. After being lost to follow-up and treatment for an average of 7.8 ± 2.0 years, strictures (n = 5; 83%) or a small-caliber esophagus (n = 4; 67%) were present in a majority of the patients, and the majority required esophageal dilation. These cases confirm that EoE can progress from an inflammation-only phenotype to a fibrostenotic phenotype in certain patients. |
format | Online Article Text |
id | pubmed-5637006 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | S. Karger AG |
record_format | MEDLINE/PubMed |
spelling | pubmed-56370062017-10-13 Progression from an Inflammatory to a Fibrostenotic Phenotype in Eosinophilic Esophagitis Koutlas, Nathaniel T. Dellon, Evan S. Case Rep Gastroenterol Case Series Previous studies have suggested that eosinophilic esophagitis (EoE) progresses from chronic inflammation to fibrostenosis. However, natural history data illustrating this progression in individual patients are lacking. Here, we present 6 patients who progressed from an inflammatory to a fibrostenotic phenotype of EoE in the absence of treatment. At the time of diagnosis, none of the patients had significant evidence of fibrostenosis, but they did have other inflammatory findings of EoE such as edema, linear furrows, or exudates. After being lost to follow-up and treatment for an average of 7.8 ± 2.0 years, strictures (n = 5; 83%) or a small-caliber esophagus (n = 4; 67%) were present in a majority of the patients, and the majority required esophageal dilation. These cases confirm that EoE can progress from an inflammation-only phenotype to a fibrostenotic phenotype in certain patients. S. Karger AG 2017-06-15 /pmc/articles/PMC5637006/ /pubmed/29033756 http://dx.doi.org/10.1159/000477391 Text en Copyright © 2017 by S. Karger AG, Basel http://creativecommons.org/licenses/by-nc/4.0/ This article is licensed under the Creative Commons Attribution-NonCommercial-4.0 International License (CC BY-NC) (http://www.karger.com/Services/OpenAccessLicense). Usage and distribution for commercial purposes requires written permission. |
spellingShingle | Case Series Koutlas, Nathaniel T. Dellon, Evan S. Progression from an Inflammatory to a Fibrostenotic Phenotype in Eosinophilic Esophagitis |
title | Progression from an Inflammatory to a Fibrostenotic Phenotype in Eosinophilic Esophagitis |
title_full | Progression from an Inflammatory to a Fibrostenotic Phenotype in Eosinophilic Esophagitis |
title_fullStr | Progression from an Inflammatory to a Fibrostenotic Phenotype in Eosinophilic Esophagitis |
title_full_unstemmed | Progression from an Inflammatory to a Fibrostenotic Phenotype in Eosinophilic Esophagitis |
title_short | Progression from an Inflammatory to a Fibrostenotic Phenotype in Eosinophilic Esophagitis |
title_sort | progression from an inflammatory to a fibrostenotic phenotype in eosinophilic esophagitis |
topic | Case Series |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5637006/ https://www.ncbi.nlm.nih.gov/pubmed/29033756 http://dx.doi.org/10.1159/000477391 |
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