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The α-melanocyte stimulating hormone/peroxisome proliferator activated receptor-γ pathway down-regulates proliferation in melanoma cell lines

BACKGROUND: The α-Melanocyte Stimulating Hormone (αMSH)/Melanocortin-1 receptor (MC1R) interaction promotes melanogenesis through the cAMP/PKA pathway. The direct induction of this pathway by Forskolin (FSK) is also known to enhance melanocyte proliferation. αMSH acts as a mitogenic agent in melanoc...

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Detalles Bibliográficos
Autores principales:	Flori, Enrica, Rosati, Eleonora, Cardinali, Giorgia, Kovacs, Daniela, Bellei, Barbara, Picardo, Mauro, Maresca, Vittoria
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2017
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5637056/ https://www.ncbi.nlm.nih.gov/pubmed/29020973 http://dx.doi.org/10.1186/s13046-017-0611-4

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