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Oscillatory Reinstatement Enhances Declarative Memory
Declarative memory recall is thought to involve the reinstatement of neural activity patterns that occurred previously during encoding. Consistent with this view, greater similarity between patterns of activity recorded during encoding and retrieval has been found to predict better memory performanc...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Society for Neuroscience
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5637119/ https://www.ncbi.nlm.nih.gov/pubmed/28912159 http://dx.doi.org/10.1523/JNEUROSCI.0265-17.2017 |
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author | Javadi, Amir-Homayoun Glen, James C. Halkiopoulos, Sara Schulz, Mei Spiers, Hugo J. |
author_facet | Javadi, Amir-Homayoun Glen, James C. Halkiopoulos, Sara Schulz, Mei Spiers, Hugo J. |
author_sort | Javadi, Amir-Homayoun |
collection | PubMed |
description | Declarative memory recall is thought to involve the reinstatement of neural activity patterns that occurred previously during encoding. Consistent with this view, greater similarity between patterns of activity recorded during encoding and retrieval has been found to predict better memory performance in a number of studies. Recent models have argued that neural oscillations may be crucial to reinstatement for successful memory retrieval. However, to date, no causal evidence has been provided to support this theory, nor has the impact of oscillatory electrical brain stimulation during encoding and retrieval been assessed. To explore this we used transcranial alternating current stimulation over the left dorsolateral prefrontal cortex of human participants [n = 70, 45 females; age mean (SD) = 22.12 (2.16)] during a declarative memory task. Participants received either the same frequency during encoding and retrieval (60–60 or 90–90 Hz) or different frequencies (60–90 or 90–60 Hz). When frequencies matched there was a significant memory improvement (at both 60 and 90 Hz) relative to sham stimulation. No improvement occurred when frequencies mismatched. Our results provide support for the role of oscillatory reinstatement in memory retrieval. SIGNIFICANCE STATEMENT Recent neurobiological models of memory have argued that large-scale neural oscillations are reinstated to support successful memory retrieval. Here we used transcranial alternating current stimulation (tACS) to test these models. tACS has recently been shown to induce neural oscillations at the frequency stimulated. We stimulated over the left dorsolateral prefrontal cortex during a declarative memory task involving learning a set of words. We found that tACS applied at the same frequency during encoding and retrieval enhances memory. We also find no difference between the two applied frequencies. Thus our results are consistent with the proposal that reinstatement of neural oscillations during retrieval supports successful memory retrieval. |
format | Online Article Text |
id | pubmed-5637119 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | Society for Neuroscience |
record_format | MEDLINE/PubMed |
spelling | pubmed-56371192017-10-25 Oscillatory Reinstatement Enhances Declarative Memory Javadi, Amir-Homayoun Glen, James C. Halkiopoulos, Sara Schulz, Mei Spiers, Hugo J. J Neurosci Research Articles Declarative memory recall is thought to involve the reinstatement of neural activity patterns that occurred previously during encoding. Consistent with this view, greater similarity between patterns of activity recorded during encoding and retrieval has been found to predict better memory performance in a number of studies. Recent models have argued that neural oscillations may be crucial to reinstatement for successful memory retrieval. However, to date, no causal evidence has been provided to support this theory, nor has the impact of oscillatory electrical brain stimulation during encoding and retrieval been assessed. To explore this we used transcranial alternating current stimulation over the left dorsolateral prefrontal cortex of human participants [n = 70, 45 females; age mean (SD) = 22.12 (2.16)] during a declarative memory task. Participants received either the same frequency during encoding and retrieval (60–60 or 90–90 Hz) or different frequencies (60–90 or 90–60 Hz). When frequencies matched there was a significant memory improvement (at both 60 and 90 Hz) relative to sham stimulation. No improvement occurred when frequencies mismatched. Our results provide support for the role of oscillatory reinstatement in memory retrieval. SIGNIFICANCE STATEMENT Recent neurobiological models of memory have argued that large-scale neural oscillations are reinstated to support successful memory retrieval. Here we used transcranial alternating current stimulation (tACS) to test these models. tACS has recently been shown to induce neural oscillations at the frequency stimulated. We stimulated over the left dorsolateral prefrontal cortex during a declarative memory task involving learning a set of words. We found that tACS applied at the same frequency during encoding and retrieval enhances memory. We also find no difference between the two applied frequencies. Thus our results are consistent with the proposal that reinstatement of neural oscillations during retrieval supports successful memory retrieval. Society for Neuroscience 2017-10-11 /pmc/articles/PMC5637119/ /pubmed/28912159 http://dx.doi.org/10.1523/JNEUROSCI.0265-17.2017 Text en Copyright © 2017 Javadi et al. https://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License Creative Commons Attribution 4.0 International (https://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution and reproduction in any medium provided that the original work is properly attributed. |
spellingShingle | Research Articles Javadi, Amir-Homayoun Glen, James C. Halkiopoulos, Sara Schulz, Mei Spiers, Hugo J. Oscillatory Reinstatement Enhances Declarative Memory |
title | Oscillatory Reinstatement Enhances Declarative Memory |
title_full | Oscillatory Reinstatement Enhances Declarative Memory |
title_fullStr | Oscillatory Reinstatement Enhances Declarative Memory |
title_full_unstemmed | Oscillatory Reinstatement Enhances Declarative Memory |
title_short | Oscillatory Reinstatement Enhances Declarative Memory |
title_sort | oscillatory reinstatement enhances declarative memory |
topic | Research Articles |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5637119/ https://www.ncbi.nlm.nih.gov/pubmed/28912159 http://dx.doi.org/10.1523/JNEUROSCI.0265-17.2017 |
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