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Opposed Effects of Dityrosine Formation in Soluble and Aggregated α-Synuclein on Fibril Growth

Parkinson's disease is the second most common neurodegenerative disease. It is characterized by aggregation of the protein α-synuclein (α-syn) in Lewy bodies, mitochondrial dysfunction, and increased oxidative stress in the substantia nigra. Oxidative stress leads to several modifications of bi...

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Detalles Bibliográficos
Autores principales:	Wördehoff, Michael M., Shaykhalishahi, Hamed, Groß, Luca, Gremer, Lothar, Stoldt, Matthias, Buell, Alexander K., Willbold, Dieter, Hoyer, Wolfgang
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Elsevier 2017
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5637163/ https://www.ncbi.nlm.nih.gov/pubmed/28918091 http://dx.doi.org/10.1016/j.jmb.2017.09.005

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