Systems metabolic engineering strategies for the production of amino acids

Systems metabolic engineering is a multidisciplinary area that integrates systems biology, synthetic biology and evolutionary engineering. It is an efficient approach for strain improvement and process optimization, and has been successfully applied in the microbial production of various chemicals i...

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Detalles Bibliográficos
Autores principales: Ma, Qian, Zhang, Quanwei, Xu, Qingyang, Zhang, Chenglin, Li, Yanjun, Fan, Xiaoguang, Xie, Xixian, Chen, Ning
Formato: Online Artículo Texto
Lenguaje:English
Publicado: KeAi Publishing 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5637227/
https://www.ncbi.nlm.nih.gov/pubmed/29062965
http://dx.doi.org/10.1016/j.synbio.2017.07.003
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author Ma, Qian
Zhang, Quanwei
Xu, Qingyang
Zhang, Chenglin
Li, Yanjun
Fan, Xiaoguang
Xie, Xixian
Chen, Ning
author_facet Ma, Qian
Zhang, Quanwei
Xu, Qingyang
Zhang, Chenglin
Li, Yanjun
Fan, Xiaoguang
Xie, Xixian
Chen, Ning
author_sort Ma, Qian
collection PubMed
description Systems metabolic engineering is a multidisciplinary area that integrates systems biology, synthetic biology and evolutionary engineering. It is an efficient approach for strain improvement and process optimization, and has been successfully applied in the microbial production of various chemicals including amino acids. In this review, systems metabolic engineering strategies including pathway-focused approaches, systems biology-based approaches, evolutionary approaches and their applications in two major amino acid producing microorganisms: Corynebacterium glutamicum and Escherichia coli, are summarized.
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spelling pubmed-56372272017-10-23 Systems metabolic engineering strategies for the production of amino acids Ma, Qian Zhang, Quanwei Xu, Qingyang Zhang, Chenglin Li, Yanjun Fan, Xiaoguang Xie, Xixian Chen, Ning Synth Syst Biotechnol Article Systems metabolic engineering is a multidisciplinary area that integrates systems biology, synthetic biology and evolutionary engineering. It is an efficient approach for strain improvement and process optimization, and has been successfully applied in the microbial production of various chemicals including amino acids. In this review, systems metabolic engineering strategies including pathway-focused approaches, systems biology-based approaches, evolutionary approaches and their applications in two major amino acid producing microorganisms: Corynebacterium glutamicum and Escherichia coli, are summarized. KeAi Publishing 2017-08-02 /pmc/articles/PMC5637227/ /pubmed/29062965 http://dx.doi.org/10.1016/j.synbio.2017.07.003 Text en © 2017 The Authors http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Article
Ma, Qian
Zhang, Quanwei
Xu, Qingyang
Zhang, Chenglin
Li, Yanjun
Fan, Xiaoguang
Xie, Xixian
Chen, Ning
Systems metabolic engineering strategies for the production of amino acids
title Systems metabolic engineering strategies for the production of amino acids
title_full Systems metabolic engineering strategies for the production of amino acids
title_fullStr Systems metabolic engineering strategies for the production of amino acids
title_full_unstemmed Systems metabolic engineering strategies for the production of amino acids
title_short Systems metabolic engineering strategies for the production of amino acids
title_sort systems metabolic engineering strategies for the production of amino acids
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5637227/
https://www.ncbi.nlm.nih.gov/pubmed/29062965
http://dx.doi.org/10.1016/j.synbio.2017.07.003
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