p16(INK4A) expression in invasive laryngeal cancer()

We examined p16 expression in tumors from a population-based sample of laryngeal cancer cases diagnosed in the U.S. Samples had been previously genotyped for HPV DNA. Overall, p16 expression was observed in laryngeal tissue from 8 of 101 (7.9%) cases. p16 expression was observed in 2 of 16 (12.5%) c...

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Detalles Bibliográficos
Autores principales: Hernandez, Brenda Y., Rahman, Mobeen, Lynch, Charles F., Cozen, Wendy, Unger, Elizabeth R., Steinau, Martin, Thompson, Trevor, Saber, Maria Sibug, Altekruse, Sean F., Goodman, Marc T., Powers, Amy, Lyu, Christopher, Saraiya, Mona
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5637278/
https://www.ncbi.nlm.nih.gov/pubmed/29034342
http://dx.doi.org/10.1016/j.pvr.2016.03.001
Descripción
Sumario:We examined p16 expression in tumors from a population-based sample of laryngeal cancer cases diagnosed in the U.S. Samples had been previously genotyped for HPV DNA. Overall, p16 expression was observed in laryngeal tissue from 8 of 101 (7.9%) cases. p16 expression was observed in 2 of 16 (12.5%) cases previously determined to be HPV DNA positive. The two cases dually positive for p16 and HPV DNA were non-keratinizing SCC and papillary SCC tumors that were positive for genotypes 18 and 35/89, respectively. Positivity for p16 and/or HPV DNA was not associated with 5-year survival (log-rank p value=0.55). Our findings support a limited role of HPV in laryngeal carcinogenesis. p16 is not a reliable surrogate for HPV status in laryngeal cancers and is not a predictor of laryngeal cancer survival.

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