A convenient UHPLC-MS/MS method for routine monitoring of plasma and brain levels of nicotine and cotinine as a tool to validate newly developed preclinical smoking model in mouse

BACKGROUND: A sensitive, rapid and selective UHPLC–MS/MS method has been developed and validated for the quantification of Nicotine (NT) and Cotinine (CN) using Continine-d (3) as internal standard (IS) as per FDA guidelines. Sample preparation involved simple protein precipitation of 20 µL mouse pl...

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Detalles Bibliográficos
Autores principales: Kaisar, Mohammad A., Kallem, Raja Reddy, Sajja, Ravi K., Sifat, Ali Ehsan, Cucullo, Luca
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2017
Materias:
Methodology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5637319/
https://www.ncbi.nlm.nih.gov/pubmed/29020944
http://dx.doi.org/10.1186/s12868-017-0389-5

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