IL-27 mediates HLA class I up-regulation, which can be inhibited by the IL-6 pathway, in HLA-deficient Small Cell Lung Cancer cells

BACKGROUND: Recently, immunotherapy with anti-PD-1 antibodies has shown clinical benefit in recurrent Small Cell Lung Cancer (SCLC). Since anti-PD-1 re-activates anti-tumor Cytotoxic T Lymphocyte (CTL) responses, it is crucial to understand the mechanisms regulating HLA class I, and PD-L1 expression...

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Detalles Bibliográficos
Autores principales: Carbotti, Grazia, Nikpoor, Amin Reza, Vacca, Paola, Gangemi, Rosaria, Giordano, Chiara, Campelli, Francesco, Ferrini, Silvano, Fabbi, Marina
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2017
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5637329/
https://www.ncbi.nlm.nih.gov/pubmed/29020964
http://dx.doi.org/10.1186/s13046-017-0608-z

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