MergeReference: A Tool for Merging Reference Panels for HLA Imputation

Recently developed computational methods allow the imputation of human leukocyte antigen (HLA) genes using intergenic single nucleotide polymorphism markers. To improve the imputation accuracy in HLA imputation, it is essential to increase the sample size and the diversity of alleles in the referenc...

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Detalles Bibliográficos
Autores principales: Cook, Seungho, Han, Buhm
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Korea Genome Organization 2017
Materias:
Application Note
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5637342/
https://www.ncbi.nlm.nih.gov/pubmed/29020726
http://dx.doi.org/10.5808/GI.2017.15.3.108
Descripción
Sumario:Recently developed computational methods allow the imputation of human leukocyte antigen (HLA) genes using intergenic single nucleotide polymorphism markers. To improve the imputation accuracy in HLA imputation, it is essential to increase the sample size and the diversity of alleles in the reference panel. Our software, MergeReference, helps achieve this goal by providing a streamlined pipeline for combining multiple reference panels into one.

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