MergeReference: A Tool for Merging Reference Panels for HLA Imputation

Recently developed computational methods allow the imputation of human leukocyte antigen (HLA) genes using intergenic single nucleotide polymorphism markers. To improve the imputation accuracy in HLA imputation, it is essential to increase the sample size and the diversity of alleles in the referenc...

Descripción completa

Detalles Bibliográficos
Autores principales: Cook, Seungho, Han, Buhm
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Korea Genome Organization 2017
Materias:
Application Note
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5637342/
https://www.ncbi.nlm.nih.gov/pubmed/29020726
http://dx.doi.org/10.5808/GI.2017.15.3.108
_version_ 1783270606516518912
author Cook, Seungho
Han, Buhm
author_facet Cook, Seungho
Han, Buhm
author_sort Cook, Seungho
collection PubMed
description Recently developed computational methods allow the imputation of human leukocyte antigen (HLA) genes using intergenic single nucleotide polymorphism markers. To improve the imputation accuracy in HLA imputation, it is essential to increase the sample size and the diversity of alleles in the reference panel. Our software, MergeReference, helps achieve this goal by providing a streamlined pipeline for combining multiple reference panels into one.
format Online
Article
Text
id pubmed-5637342
institution National Center for Biotechnology Information
language English
publishDate 2017
publisher Korea Genome Organization
record_format MEDLINE/PubMed
spelling pubmed-56373422017-10-17 MergeReference: A Tool for Merging Reference Panels for HLA Imputation Cook, Seungho Han, Buhm Genomics Inform Application Note Recently developed computational methods allow the imputation of human leukocyte antigen (HLA) genes using intergenic single nucleotide polymorphism markers. To improve the imputation accuracy in HLA imputation, it is essential to increase the sample size and the diversity of alleles in the reference panel. Our software, MergeReference, helps achieve this goal by providing a streamlined pipeline for combining multiple reference panels into one. Korea Genome Organization 2017-09 2017-09-28 /pmc/articles/PMC5637342/ /pubmed/29020726 http://dx.doi.org/10.5808/GI.2017.15.3.108 Text en Copyright © 2017 by the Korea Genome Organization It is identical to the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/).
spellingShingle Application Note
Cook, Seungho
Han, Buhm
MergeReference: A Tool for Merging Reference Panels for HLA Imputation
title MergeReference: A Tool for Merging Reference Panels for HLA Imputation
title_full MergeReference: A Tool for Merging Reference Panels for HLA Imputation
title_fullStr MergeReference: A Tool for Merging Reference Panels for HLA Imputation
title_full_unstemmed MergeReference: A Tool for Merging Reference Panels for HLA Imputation
title_short MergeReference: A Tool for Merging Reference Panels for HLA Imputation
title_sort mergereference: a tool for merging reference panels for hla imputation
topic Application Note
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5637342/
https://www.ncbi.nlm.nih.gov/pubmed/29020726
http://dx.doi.org/10.5808/GI.2017.15.3.108
work_keys_str_mv AT cookseungho mergereferenceatoolformergingreferencepanelsforhlaimputation
AT hanbuhm mergereferenceatoolformergingreferencepanelsforhlaimputation

Ejemplares similares