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A multi-national comparison of antipsychotic drug use in children and adolescents, 2005–2012

Over the last decades, an increase in antipsychotic (AP) prescribing and a shift from first-generation antipsychotics (FGA) to second-generation antipsychotics (SGA) among youth have been reported. However, most AP prescriptions for youth are off-label, and there are worrying long-term safety data i...

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Autores principales: Kalverdijk, Luuk J., Bachmann, Christian J., Aagaard, Lise, Burcu, Mehmet, Glaeske, Gerd, Hoffmann, Falk, Petersen, Irene, Schuiling-Veninga, Catharina C. M., Wijlaars, Linda P., Zito, Julie M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5637352/
https://www.ncbi.nlm.nih.gov/pubmed/29046716
http://dx.doi.org/10.1186/s13034-017-0192-1
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author Kalverdijk, Luuk J.
Bachmann, Christian J.
Aagaard, Lise
Burcu, Mehmet
Glaeske, Gerd
Hoffmann, Falk
Petersen, Irene
Schuiling-Veninga, Catharina C. M.
Wijlaars, Linda P.
Zito, Julie M.
author_facet Kalverdijk, Luuk J.
Bachmann, Christian J.
Aagaard, Lise
Burcu, Mehmet
Glaeske, Gerd
Hoffmann, Falk
Petersen, Irene
Schuiling-Veninga, Catharina C. M.
Wijlaars, Linda P.
Zito, Julie M.
author_sort Kalverdijk, Luuk J.
collection PubMed
description Over the last decades, an increase in antipsychotic (AP) prescribing and a shift from first-generation antipsychotics (FGA) to second-generation antipsychotics (SGA) among youth have been reported. However, most AP prescriptions for youth are off-label, and there are worrying long-term safety data in youth. The objective of this study was to assess multinational trends in AP use among children and adolescents. A repeated cross-sectional design was applied to cohorts from varied sources from Denmark, Germany, the Netherlands, the United Kingdom (UK) and the United States (US) for calendar years 2005/2006–2012. The annual prevalence of AP use was assessed, stratified by age group, sex and subclass (FGA/SGA). The prevalence of AP use increased from 0.78 to 1.03% in the Netherlands’ data, from 0.26 to 0.48% in the Danish cohort, from 0.23 to 0.32% in the German cohort, and from 0.1 to 0.14% in the UK cohort. In the US cohort, AP use decreased from 0.94 to 0.79%. In the US cohort, nearly all ATP dispensings were for SGA, while among the European cohorts the proportion of SGA dispensings grew to nearly 75% of all AP dispensings. With the exception of the Netherlands, AP use prevalence was highest in 15–19 year-olds. So, from 2005/6 to 2012, AP use prevalence increased in all youth cohorts from European countries and decreased in the US cohort. SGA were favoured in all countries’ cohorts.
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spelling pubmed-56373522017-10-18 A multi-national comparison of antipsychotic drug use in children and adolescents, 2005–2012 Kalverdijk, Luuk J. Bachmann, Christian J. Aagaard, Lise Burcu, Mehmet Glaeske, Gerd Hoffmann, Falk Petersen, Irene Schuiling-Veninga, Catharina C. M. Wijlaars, Linda P. Zito, Julie M. Child Adolesc Psychiatry Ment Health Research Article Over the last decades, an increase in antipsychotic (AP) prescribing and a shift from first-generation antipsychotics (FGA) to second-generation antipsychotics (SGA) among youth have been reported. However, most AP prescriptions for youth are off-label, and there are worrying long-term safety data in youth. The objective of this study was to assess multinational trends in AP use among children and adolescents. A repeated cross-sectional design was applied to cohorts from varied sources from Denmark, Germany, the Netherlands, the United Kingdom (UK) and the United States (US) for calendar years 2005/2006–2012. The annual prevalence of AP use was assessed, stratified by age group, sex and subclass (FGA/SGA). The prevalence of AP use increased from 0.78 to 1.03% in the Netherlands’ data, from 0.26 to 0.48% in the Danish cohort, from 0.23 to 0.32% in the German cohort, and from 0.1 to 0.14% in the UK cohort. In the US cohort, AP use decreased from 0.94 to 0.79%. In the US cohort, nearly all ATP dispensings were for SGA, while among the European cohorts the proportion of SGA dispensings grew to nearly 75% of all AP dispensings. With the exception of the Netherlands, AP use prevalence was highest in 15–19 year-olds. So, from 2005/6 to 2012, AP use prevalence increased in all youth cohorts from European countries and decreased in the US cohort. SGA were favoured in all countries’ cohorts. BioMed Central 2017-10-11 /pmc/articles/PMC5637352/ /pubmed/29046716 http://dx.doi.org/10.1186/s13034-017-0192-1 Text en © The Author(s) 2017 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Research Article
Kalverdijk, Luuk J.
Bachmann, Christian J.
Aagaard, Lise
Burcu, Mehmet
Glaeske, Gerd
Hoffmann, Falk
Petersen, Irene
Schuiling-Veninga, Catharina C. M.
Wijlaars, Linda P.
Zito, Julie M.
A multi-national comparison of antipsychotic drug use in children and adolescents, 2005–2012
title A multi-national comparison of antipsychotic drug use in children and adolescents, 2005–2012
title_full A multi-national comparison of antipsychotic drug use in children and adolescents, 2005–2012
title_fullStr A multi-national comparison of antipsychotic drug use in children and adolescents, 2005–2012
title_full_unstemmed A multi-national comparison of antipsychotic drug use in children and adolescents, 2005–2012
title_short A multi-national comparison of antipsychotic drug use in children and adolescents, 2005–2012
title_sort multi-national comparison of antipsychotic drug use in children and adolescents, 2005–2012
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5637352/
https://www.ncbi.nlm.nih.gov/pubmed/29046716
http://dx.doi.org/10.1186/s13034-017-0192-1
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