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A multi-national comparison of antipsychotic drug use in children and adolescents, 2005–2012
Over the last decades, an increase in antipsychotic (AP) prescribing and a shift from first-generation antipsychotics (FGA) to second-generation antipsychotics (SGA) among youth have been reported. However, most AP prescriptions for youth are off-label, and there are worrying long-term safety data i...
Autores principales: | , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5637352/ https://www.ncbi.nlm.nih.gov/pubmed/29046716 http://dx.doi.org/10.1186/s13034-017-0192-1 |
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author | Kalverdijk, Luuk J. Bachmann, Christian J. Aagaard, Lise Burcu, Mehmet Glaeske, Gerd Hoffmann, Falk Petersen, Irene Schuiling-Veninga, Catharina C. M. Wijlaars, Linda P. Zito, Julie M. |
author_facet | Kalverdijk, Luuk J. Bachmann, Christian J. Aagaard, Lise Burcu, Mehmet Glaeske, Gerd Hoffmann, Falk Petersen, Irene Schuiling-Veninga, Catharina C. M. Wijlaars, Linda P. Zito, Julie M. |
author_sort | Kalverdijk, Luuk J. |
collection | PubMed |
description | Over the last decades, an increase in antipsychotic (AP) prescribing and a shift from first-generation antipsychotics (FGA) to second-generation antipsychotics (SGA) among youth have been reported. However, most AP prescriptions for youth are off-label, and there are worrying long-term safety data in youth. The objective of this study was to assess multinational trends in AP use among children and adolescents. A repeated cross-sectional design was applied to cohorts from varied sources from Denmark, Germany, the Netherlands, the United Kingdom (UK) and the United States (US) for calendar years 2005/2006–2012. The annual prevalence of AP use was assessed, stratified by age group, sex and subclass (FGA/SGA). The prevalence of AP use increased from 0.78 to 1.03% in the Netherlands’ data, from 0.26 to 0.48% in the Danish cohort, from 0.23 to 0.32% in the German cohort, and from 0.1 to 0.14% in the UK cohort. In the US cohort, AP use decreased from 0.94 to 0.79%. In the US cohort, nearly all ATP dispensings were for SGA, while among the European cohorts the proportion of SGA dispensings grew to nearly 75% of all AP dispensings. With the exception of the Netherlands, AP use prevalence was highest in 15–19 year-olds. So, from 2005/6 to 2012, AP use prevalence increased in all youth cohorts from European countries and decreased in the US cohort. SGA were favoured in all countries’ cohorts. |
format | Online Article Text |
id | pubmed-5637352 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-56373522017-10-18 A multi-national comparison of antipsychotic drug use in children and adolescents, 2005–2012 Kalverdijk, Luuk J. Bachmann, Christian J. Aagaard, Lise Burcu, Mehmet Glaeske, Gerd Hoffmann, Falk Petersen, Irene Schuiling-Veninga, Catharina C. M. Wijlaars, Linda P. Zito, Julie M. Child Adolesc Psychiatry Ment Health Research Article Over the last decades, an increase in antipsychotic (AP) prescribing and a shift from first-generation antipsychotics (FGA) to second-generation antipsychotics (SGA) among youth have been reported. However, most AP prescriptions for youth are off-label, and there are worrying long-term safety data in youth. The objective of this study was to assess multinational trends in AP use among children and adolescents. A repeated cross-sectional design was applied to cohorts from varied sources from Denmark, Germany, the Netherlands, the United Kingdom (UK) and the United States (US) for calendar years 2005/2006–2012. The annual prevalence of AP use was assessed, stratified by age group, sex and subclass (FGA/SGA). The prevalence of AP use increased from 0.78 to 1.03% in the Netherlands’ data, from 0.26 to 0.48% in the Danish cohort, from 0.23 to 0.32% in the German cohort, and from 0.1 to 0.14% in the UK cohort. In the US cohort, AP use decreased from 0.94 to 0.79%. In the US cohort, nearly all ATP dispensings were for SGA, while among the European cohorts the proportion of SGA dispensings grew to nearly 75% of all AP dispensings. With the exception of the Netherlands, AP use prevalence was highest in 15–19 year-olds. So, from 2005/6 to 2012, AP use prevalence increased in all youth cohorts from European countries and decreased in the US cohort. SGA were favoured in all countries’ cohorts. BioMed Central 2017-10-11 /pmc/articles/PMC5637352/ /pubmed/29046716 http://dx.doi.org/10.1186/s13034-017-0192-1 Text en © The Author(s) 2017 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated. |
spellingShingle | Research Article Kalverdijk, Luuk J. Bachmann, Christian J. Aagaard, Lise Burcu, Mehmet Glaeske, Gerd Hoffmann, Falk Petersen, Irene Schuiling-Veninga, Catharina C. M. Wijlaars, Linda P. Zito, Julie M. A multi-national comparison of antipsychotic drug use in children and adolescents, 2005–2012 |
title | A multi-national comparison of antipsychotic drug use in children and adolescents, 2005–2012 |
title_full | A multi-national comparison of antipsychotic drug use in children and adolescents, 2005–2012 |
title_fullStr | A multi-national comparison of antipsychotic drug use in children and adolescents, 2005–2012 |
title_full_unstemmed | A multi-national comparison of antipsychotic drug use in children and adolescents, 2005–2012 |
title_short | A multi-national comparison of antipsychotic drug use in children and adolescents, 2005–2012 |
title_sort | multi-national comparison of antipsychotic drug use in children and adolescents, 2005–2012 |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5637352/ https://www.ncbi.nlm.nih.gov/pubmed/29046716 http://dx.doi.org/10.1186/s13034-017-0192-1 |
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