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A multiple genome analysis of Mycobacterium tuberculosis reveals specific novel genes and mutations associated with pyrazinamide resistance

BACKGROUND: Tuberculosis (TB) is a major global health problem and drug resistance compromises the efforts to control this disease. Pyrazinamide (PZA) is an important drug used in both first and second line treatment regimes. However, its complete mechanism of action and resistance remains unclear....

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Detalles Bibliográficos
Autores principales:	Sheen, Patricia, Requena, David, Gushiken, Eduardo, Gilman, Robert H., Antiparra, Ricardo, Lucero, Bryan, Lizárraga, Pilar, Cieza, Basilio, Roncal, Elisa, Grandjean, Louis, Pain, Arnab, McNerney, Ruth, Clark, Taane G., Moore, David, Zimic, Mirko
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2017
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5637355/ https://www.ncbi.nlm.nih.gov/pubmed/29020922 http://dx.doi.org/10.1186/s12864-017-4146-z

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