Cargando…

Fatal Leptospira spp./Zika Virus Coinfection—Puerto Rico, 2016

Coinfection with pathogens that cause acute febrile illness (AFI) can complicate patient diagnosis and management. This report describes a fatal case of Leptospira spp./Zika virus (ZIKV) coinfection in Puerto Rico. The patient presented with a 5-day history of AFI; reported behavioral risk factors f...

Descripción completa

Detalles Bibliográficos
Autores principales: Neaterour, Paige, Rivera, Aidsa, Galloway, Renee L., Negrón, Myriam Garcia, Rivera-Garcia, Brenda, Sharp, Tyler M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The American Society of Tropical Medicine and Hygiene 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5637617/
https://www.ncbi.nlm.nih.gov/pubmed/28722594
http://dx.doi.org/10.4269/ajtmh.17-0250
_version_ 1783270637815463936
author Neaterour, Paige
Rivera, Aidsa
Galloway, Renee L.
Negrón, Myriam Garcia
Rivera-Garcia, Brenda
Sharp, Tyler M.
author_facet Neaterour, Paige
Rivera, Aidsa
Galloway, Renee L.
Negrón, Myriam Garcia
Rivera-Garcia, Brenda
Sharp, Tyler M.
author_sort Neaterour, Paige
collection PubMed
description Coinfection with pathogens that cause acute febrile illness (AFI) can complicate patient diagnosis and management. This report describes a fatal case of Leptospira spp./Zika virus (ZIKV) coinfection in Puerto Rico. The patient presented with a 5-day history of AFI; reported behavioral risk factors for leptospirosis; was diagnosed with possible leptospirosis, dengue, chikungunya, or ZIKV disease; and received appropriate treatment for leptospirosis and dengue. Following a 3-day hospitalization, the patient died due to acute gastrointestinal hemorrhage, and kidney and liver failure. Serologic diagnostic testing for leptospirosis and ZIKV disease was negative; however, molecular diagnostic testing performed postmortem was positive for detection of Leptospira spp. and ZIKV nucleic acid. This case demonstrates the need for continued clinical awareness of leptospirosis in areas experiencing outbreaks of pathogens that cause AFI and the need for evaluation of coinfection with AFI-causing pathogens as a risk factor for increased severity of disease.
format Online
Article
Text
id pubmed-5637617
institution National Center for Biotechnology Information
language English
publishDate 2017
publisher The American Society of Tropical Medicine and Hygiene
record_format MEDLINE/PubMed
spelling pubmed-56376172018-04-30 Fatal Leptospira spp./Zika Virus Coinfection—Puerto Rico, 2016 Neaterour, Paige Rivera, Aidsa Galloway, Renee L. Negrón, Myriam Garcia Rivera-Garcia, Brenda Sharp, Tyler M. Am J Trop Med Hyg Articles Coinfection with pathogens that cause acute febrile illness (AFI) can complicate patient diagnosis and management. This report describes a fatal case of Leptospira spp./Zika virus (ZIKV) coinfection in Puerto Rico. The patient presented with a 5-day history of AFI; reported behavioral risk factors for leptospirosis; was diagnosed with possible leptospirosis, dengue, chikungunya, or ZIKV disease; and received appropriate treatment for leptospirosis and dengue. Following a 3-day hospitalization, the patient died due to acute gastrointestinal hemorrhage, and kidney and liver failure. Serologic diagnostic testing for leptospirosis and ZIKV disease was negative; however, molecular diagnostic testing performed postmortem was positive for detection of Leptospira spp. and ZIKV nucleic acid. This case demonstrates the need for continued clinical awareness of leptospirosis in areas experiencing outbreaks of pathogens that cause AFI and the need for evaluation of coinfection with AFI-causing pathogens as a risk factor for increased severity of disease. The American Society of Tropical Medicine and Hygiene 2017-10-11 2017-06-26 /pmc/articles/PMC5637617/ /pubmed/28722594 http://dx.doi.org/10.4269/ajtmh.17-0250 Text en © The American Society of Tropical Medicine and Hygiene This is an open-access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Articles
Neaterour, Paige
Rivera, Aidsa
Galloway, Renee L.
Negrón, Myriam Garcia
Rivera-Garcia, Brenda
Sharp, Tyler M.
Fatal Leptospira spp./Zika Virus Coinfection—Puerto Rico, 2016
title Fatal Leptospira spp./Zika Virus Coinfection—Puerto Rico, 2016
title_full Fatal Leptospira spp./Zika Virus Coinfection—Puerto Rico, 2016
title_fullStr Fatal Leptospira spp./Zika Virus Coinfection—Puerto Rico, 2016
title_full_unstemmed Fatal Leptospira spp./Zika Virus Coinfection—Puerto Rico, 2016
title_short Fatal Leptospira spp./Zika Virus Coinfection—Puerto Rico, 2016
title_sort fatal leptospira spp./zika virus coinfection—puerto rico, 2016
topic Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5637617/
https://www.ncbi.nlm.nih.gov/pubmed/28722594
http://dx.doi.org/10.4269/ajtmh.17-0250
work_keys_str_mv AT neaterourpaige fatalleptospirasppzikaviruscoinfectionpuertorico2016
AT riveraaidsa fatalleptospirasppzikaviruscoinfectionpuertorico2016
AT gallowayreneel fatalleptospirasppzikaviruscoinfectionpuertorico2016
AT negronmyriamgarcia fatalleptospirasppzikaviruscoinfectionpuertorico2016
AT riveragarciabrenda fatalleptospirasppzikaviruscoinfectionpuertorico2016
AT sharptylerm fatalleptospirasppzikaviruscoinfectionpuertorico2016