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Fatal Leptospira spp./Zika Virus Coinfection—Puerto Rico, 2016
Coinfection with pathogens that cause acute febrile illness (AFI) can complicate patient diagnosis and management. This report describes a fatal case of Leptospira spp./Zika virus (ZIKV) coinfection in Puerto Rico. The patient presented with a 5-day history of AFI; reported behavioral risk factors f...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
The American Society of Tropical Medicine and Hygiene
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5637617/ https://www.ncbi.nlm.nih.gov/pubmed/28722594 http://dx.doi.org/10.4269/ajtmh.17-0250 |
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author | Neaterour, Paige Rivera, Aidsa Galloway, Renee L. Negrón, Myriam Garcia Rivera-Garcia, Brenda Sharp, Tyler M. |
author_facet | Neaterour, Paige Rivera, Aidsa Galloway, Renee L. Negrón, Myriam Garcia Rivera-Garcia, Brenda Sharp, Tyler M. |
author_sort | Neaterour, Paige |
collection | PubMed |
description | Coinfection with pathogens that cause acute febrile illness (AFI) can complicate patient diagnosis and management. This report describes a fatal case of Leptospira spp./Zika virus (ZIKV) coinfection in Puerto Rico. The patient presented with a 5-day history of AFI; reported behavioral risk factors for leptospirosis; was diagnosed with possible leptospirosis, dengue, chikungunya, or ZIKV disease; and received appropriate treatment for leptospirosis and dengue. Following a 3-day hospitalization, the patient died due to acute gastrointestinal hemorrhage, and kidney and liver failure. Serologic diagnostic testing for leptospirosis and ZIKV disease was negative; however, molecular diagnostic testing performed postmortem was positive for detection of Leptospira spp. and ZIKV nucleic acid. This case demonstrates the need for continued clinical awareness of leptospirosis in areas experiencing outbreaks of pathogens that cause AFI and the need for evaluation of coinfection with AFI-causing pathogens as a risk factor for increased severity of disease. |
format | Online Article Text |
id | pubmed-5637617 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | The American Society of Tropical Medicine and Hygiene |
record_format | MEDLINE/PubMed |
spelling | pubmed-56376172018-04-30 Fatal Leptospira spp./Zika Virus Coinfection—Puerto Rico, 2016 Neaterour, Paige Rivera, Aidsa Galloway, Renee L. Negrón, Myriam Garcia Rivera-Garcia, Brenda Sharp, Tyler M. Am J Trop Med Hyg Articles Coinfection with pathogens that cause acute febrile illness (AFI) can complicate patient diagnosis and management. This report describes a fatal case of Leptospira spp./Zika virus (ZIKV) coinfection in Puerto Rico. The patient presented with a 5-day history of AFI; reported behavioral risk factors for leptospirosis; was diagnosed with possible leptospirosis, dengue, chikungunya, or ZIKV disease; and received appropriate treatment for leptospirosis and dengue. Following a 3-day hospitalization, the patient died due to acute gastrointestinal hemorrhage, and kidney and liver failure. Serologic diagnostic testing for leptospirosis and ZIKV disease was negative; however, molecular diagnostic testing performed postmortem was positive for detection of Leptospira spp. and ZIKV nucleic acid. This case demonstrates the need for continued clinical awareness of leptospirosis in areas experiencing outbreaks of pathogens that cause AFI and the need for evaluation of coinfection with AFI-causing pathogens as a risk factor for increased severity of disease. The American Society of Tropical Medicine and Hygiene 2017-10-11 2017-06-26 /pmc/articles/PMC5637617/ /pubmed/28722594 http://dx.doi.org/10.4269/ajtmh.17-0250 Text en © The American Society of Tropical Medicine and Hygiene This is an open-access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. |
spellingShingle | Articles Neaterour, Paige Rivera, Aidsa Galloway, Renee L. Negrón, Myriam Garcia Rivera-Garcia, Brenda Sharp, Tyler M. Fatal Leptospira spp./Zika Virus Coinfection—Puerto Rico, 2016 |
title | Fatal Leptospira spp./Zika Virus Coinfection—Puerto Rico, 2016 |
title_full | Fatal Leptospira spp./Zika Virus Coinfection—Puerto Rico, 2016 |
title_fullStr | Fatal Leptospira spp./Zika Virus Coinfection—Puerto Rico, 2016 |
title_full_unstemmed | Fatal Leptospira spp./Zika Virus Coinfection—Puerto Rico, 2016 |
title_short | Fatal Leptospira spp./Zika Virus Coinfection—Puerto Rico, 2016 |
title_sort | fatal leptospira spp./zika virus coinfection—puerto rico, 2016 |
topic | Articles |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5637617/ https://www.ncbi.nlm.nih.gov/pubmed/28722594 http://dx.doi.org/10.4269/ajtmh.17-0250 |
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