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The association between sex hormone-binding globulin and type 2 diabetes in Nigerian men

BACKGROUND: Epidemiological studies have shown that sex hormone-binding globulin (SHBG) has a role in glucose homeostasis in both men and women. However, a prospective study on Japanese-American subjects concluded that SHBG was not a significant risk factor in either men or women, suggesting ethnic...

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Autores principales: Abbiyesuku, Fayefori M., Agbakwuru, Augustine N., Olawale, Olatunbosun O.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: AOSIS OpenJournals 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5637783/
https://www.ncbi.nlm.nih.gov/pubmed/29043159
http://dx.doi.org/10.4102/ajlm.v2i1.44
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author Abbiyesuku, Fayefori M.
Agbakwuru, Augustine N.
Olawale, Olatunbosun O.
author_facet Abbiyesuku, Fayefori M.
Agbakwuru, Augustine N.
Olawale, Olatunbosun O.
author_sort Abbiyesuku, Fayefori M.
collection PubMed
description BACKGROUND: Epidemiological studies have shown that sex hormone-binding globulin (SHBG) has a role in glucose homeostasis in both men and women. However, a prospective study on Japanese-American subjects concluded that SHBG was not a significant risk factor in either men or women, suggesting ethnic differences. We were not aware of any evaluation of SHBG in subjects of African ancestry. OBJECTIVES: We investigated the association between SHBG and insulin resistance in type 2 diabetic diabetic men in a hospital in Nigeria. METHOD: Forty-eight male subjects with type 2 diabetes and 20 non-diabetic male subjects were recruited in this cross-sectional hospital-based study by the convenient sampling method. Height and circumferences around the waist and hip were measured to the nearest 0.5 cm and the waist–hip ratio was calculated from this measurement. Weight was measured and body mass index was calculated. Fasting plasma glucose concentration was measured by the glucose oxidase method with a between-run coefficient of variation of 3%. Insulin and SHBG were measured by means of enzyme-linked immunosorbent assay (ELISA). RESULTS: There was a statistically-significant difference between test results for the diabetic and non-diabetic patients. The mean SHBG concentration was higher in the non-diabetic group (42.2 nmol/L) than the diabetic group (30.5 nmol/L). A significant inverse association between insulin resistance and SHBG was observed (r = 0.353, p < 0.015). CONCLUSION: This study supported earlier observations that a significant inverse correlation exists between SHBG and insulin resistance and provides evidence that the relationship may extend to type 2 diabetic men of African ancestry in Nigeria.
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spelling pubmed-56377832017-10-17 The association between sex hormone-binding globulin and type 2 diabetes in Nigerian men Abbiyesuku, Fayefori M. Agbakwuru, Augustine N. Olawale, Olatunbosun O. Afr J Lab Med Original Research BACKGROUND: Epidemiological studies have shown that sex hormone-binding globulin (SHBG) has a role in glucose homeostasis in both men and women. However, a prospective study on Japanese-American subjects concluded that SHBG was not a significant risk factor in either men or women, suggesting ethnic differences. We were not aware of any evaluation of SHBG in subjects of African ancestry. OBJECTIVES: We investigated the association between SHBG and insulin resistance in type 2 diabetic diabetic men in a hospital in Nigeria. METHOD: Forty-eight male subjects with type 2 diabetes and 20 non-diabetic male subjects were recruited in this cross-sectional hospital-based study by the convenient sampling method. Height and circumferences around the waist and hip were measured to the nearest 0.5 cm and the waist–hip ratio was calculated from this measurement. Weight was measured and body mass index was calculated. Fasting plasma glucose concentration was measured by the glucose oxidase method with a between-run coefficient of variation of 3%. Insulin and SHBG were measured by means of enzyme-linked immunosorbent assay (ELISA). RESULTS: There was a statistically-significant difference between test results for the diabetic and non-diabetic patients. The mean SHBG concentration was higher in the non-diabetic group (42.2 nmol/L) than the diabetic group (30.5 nmol/L). A significant inverse association between insulin resistance and SHBG was observed (r = 0.353, p < 0.015). CONCLUSION: This study supported earlier observations that a significant inverse correlation exists between SHBG and insulin resistance and provides evidence that the relationship may extend to type 2 diabetic men of African ancestry in Nigeria. AOSIS OpenJournals 2013-07-24 /pmc/articles/PMC5637783/ /pubmed/29043159 http://dx.doi.org/10.4102/ajlm.v2i1.44 Text en © 2013. The Authors https://creativecommons.org/licenses/by/4.0/ Licensee: AOSIS OpenJournals. This work is licensed under the Creative Commons Attribution License.
spellingShingle Original Research
Abbiyesuku, Fayefori M.
Agbakwuru, Augustine N.
Olawale, Olatunbosun O.
The association between sex hormone-binding globulin and type 2 diabetes in Nigerian men
title The association between sex hormone-binding globulin and type 2 diabetes in Nigerian men
title_full The association between sex hormone-binding globulin and type 2 diabetes in Nigerian men
title_fullStr The association between sex hormone-binding globulin and type 2 diabetes in Nigerian men
title_full_unstemmed The association between sex hormone-binding globulin and type 2 diabetes in Nigerian men
title_short The association between sex hormone-binding globulin and type 2 diabetes in Nigerian men
title_sort association between sex hormone-binding globulin and type 2 diabetes in nigerian men
topic Original Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5637783/
https://www.ncbi.nlm.nih.gov/pubmed/29043159
http://dx.doi.org/10.4102/ajlm.v2i1.44
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