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The association between sex hormone-binding globulin and type 2 diabetes in Nigerian men
BACKGROUND: Epidemiological studies have shown that sex hormone-binding globulin (SHBG) has a role in glucose homeostasis in both men and women. However, a prospective study on Japanese-American subjects concluded that SHBG was not a significant risk factor in either men or women, suggesting ethnic...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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AOSIS OpenJournals
2013
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5637783/ https://www.ncbi.nlm.nih.gov/pubmed/29043159 http://dx.doi.org/10.4102/ajlm.v2i1.44 |
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author | Abbiyesuku, Fayefori M. Agbakwuru, Augustine N. Olawale, Olatunbosun O. |
author_facet | Abbiyesuku, Fayefori M. Agbakwuru, Augustine N. Olawale, Olatunbosun O. |
author_sort | Abbiyesuku, Fayefori M. |
collection | PubMed |
description | BACKGROUND: Epidemiological studies have shown that sex hormone-binding globulin (SHBG) has a role in glucose homeostasis in both men and women. However, a prospective study on Japanese-American subjects concluded that SHBG was not a significant risk factor in either men or women, suggesting ethnic differences. We were not aware of any evaluation of SHBG in subjects of African ancestry. OBJECTIVES: We investigated the association between SHBG and insulin resistance in type 2 diabetic diabetic men in a hospital in Nigeria. METHOD: Forty-eight male subjects with type 2 diabetes and 20 non-diabetic male subjects were recruited in this cross-sectional hospital-based study by the convenient sampling method. Height and circumferences around the waist and hip were measured to the nearest 0.5 cm and the waist–hip ratio was calculated from this measurement. Weight was measured and body mass index was calculated. Fasting plasma glucose concentration was measured by the glucose oxidase method with a between-run coefficient of variation of 3%. Insulin and SHBG were measured by means of enzyme-linked immunosorbent assay (ELISA). RESULTS: There was a statistically-significant difference between test results for the diabetic and non-diabetic patients. The mean SHBG concentration was higher in the non-diabetic group (42.2 nmol/L) than the diabetic group (30.5 nmol/L). A significant inverse association between insulin resistance and SHBG was observed (r = 0.353, p < 0.015). CONCLUSION: This study supported earlier observations that a significant inverse correlation exists between SHBG and insulin resistance and provides evidence that the relationship may extend to type 2 diabetic men of African ancestry in Nigeria. |
format | Online Article Text |
id | pubmed-5637783 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2013 |
publisher | AOSIS OpenJournals |
record_format | MEDLINE/PubMed |
spelling | pubmed-56377832017-10-17 The association between sex hormone-binding globulin and type 2 diabetes in Nigerian men Abbiyesuku, Fayefori M. Agbakwuru, Augustine N. Olawale, Olatunbosun O. Afr J Lab Med Original Research BACKGROUND: Epidemiological studies have shown that sex hormone-binding globulin (SHBG) has a role in glucose homeostasis in both men and women. However, a prospective study on Japanese-American subjects concluded that SHBG was not a significant risk factor in either men or women, suggesting ethnic differences. We were not aware of any evaluation of SHBG in subjects of African ancestry. OBJECTIVES: We investigated the association between SHBG and insulin resistance in type 2 diabetic diabetic men in a hospital in Nigeria. METHOD: Forty-eight male subjects with type 2 diabetes and 20 non-diabetic male subjects were recruited in this cross-sectional hospital-based study by the convenient sampling method. Height and circumferences around the waist and hip were measured to the nearest 0.5 cm and the waist–hip ratio was calculated from this measurement. Weight was measured and body mass index was calculated. Fasting plasma glucose concentration was measured by the glucose oxidase method with a between-run coefficient of variation of 3%. Insulin and SHBG were measured by means of enzyme-linked immunosorbent assay (ELISA). RESULTS: There was a statistically-significant difference between test results for the diabetic and non-diabetic patients. The mean SHBG concentration was higher in the non-diabetic group (42.2 nmol/L) than the diabetic group (30.5 nmol/L). A significant inverse association between insulin resistance and SHBG was observed (r = 0.353, p < 0.015). CONCLUSION: This study supported earlier observations that a significant inverse correlation exists between SHBG and insulin resistance and provides evidence that the relationship may extend to type 2 diabetic men of African ancestry in Nigeria. AOSIS OpenJournals 2013-07-24 /pmc/articles/PMC5637783/ /pubmed/29043159 http://dx.doi.org/10.4102/ajlm.v2i1.44 Text en © 2013. The Authors https://creativecommons.org/licenses/by/4.0/ Licensee: AOSIS OpenJournals. This work is licensed under the Creative Commons Attribution License. |
spellingShingle | Original Research Abbiyesuku, Fayefori M. Agbakwuru, Augustine N. Olawale, Olatunbosun O. The association between sex hormone-binding globulin and type 2 diabetes in Nigerian men |
title | The association between sex hormone-binding globulin and type 2 diabetes in Nigerian men |
title_full | The association between sex hormone-binding globulin and type 2 diabetes in Nigerian men |
title_fullStr | The association between sex hormone-binding globulin and type 2 diabetes in Nigerian men |
title_full_unstemmed | The association between sex hormone-binding globulin and type 2 diabetes in Nigerian men |
title_short | The association between sex hormone-binding globulin and type 2 diabetes in Nigerian men |
title_sort | association between sex hormone-binding globulin and type 2 diabetes in nigerian men |
topic | Original Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5637783/ https://www.ncbi.nlm.nih.gov/pubmed/29043159 http://dx.doi.org/10.4102/ajlm.v2i1.44 |
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