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Maternal and Perinatal Outcome in Women with Systemic Lupus Erythematosus: A Retrospective Bicenter Cohort Study

OBJECTIVE: To investigate disease activity around and during pregnancy and pregnancy outcome in women with systemic lupus erythematosus (SLE) considering antiphospholipid antibody status. Moreover, differences between first and consecutive pregnancies were examined. METHODS: Pregnancies > 16 week...

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Autores principales: Kroese, Sylvia J., Abheiden, Carolien N. H., Blomjous, Birgit S., van Laar, Jacob M., Derksen, Ronald W. H. M., Bultink, Irene E. M., Voskuyl, Alexandre E., Lely, A. Titia, de Boer, Marjon A., de Vries, Johanna I. P., Fritsch-Stork, Ruth D. E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5637847/
https://www.ncbi.nlm.nih.gov/pubmed/29094052
http://dx.doi.org/10.1155/2017/8245879
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author Kroese, Sylvia J.
Abheiden, Carolien N. H.
Blomjous, Birgit S.
van Laar, Jacob M.
Derksen, Ronald W. H. M.
Bultink, Irene E. M.
Voskuyl, Alexandre E.
Lely, A. Titia
de Boer, Marjon A.
de Vries, Johanna I. P.
Fritsch-Stork, Ruth D. E.
author_facet Kroese, Sylvia J.
Abheiden, Carolien N. H.
Blomjous, Birgit S.
van Laar, Jacob M.
Derksen, Ronald W. H. M.
Bultink, Irene E. M.
Voskuyl, Alexandre E.
Lely, A. Titia
de Boer, Marjon A.
de Vries, Johanna I. P.
Fritsch-Stork, Ruth D. E.
author_sort Kroese, Sylvia J.
collection PubMed
description OBJECTIVE: To investigate disease activity around and during pregnancy and pregnancy outcome in women with systemic lupus erythematosus (SLE) considering antiphospholipid antibody status. Moreover, differences between first and consecutive pregnancies were examined. METHODS: Pregnancies > 16 weeks gestation of SLE patients receiving joint care from rheumatologists and gynecologists in two tertiary centers in the Netherlands between 2000 and 2015 were included. Disease activity, flare rate, and pregnancy outcomes and complications were assessed. RESULTS: Ninety-six women (84% Caucasian) with 144 pregnancies were included. The median SLE(P)DAI score was 2 before, during, and after pregnancy. Flare rates were 6.3%, 20.1%, and 15.3%, respectively. Severe hypertensive disorder of pregnancy, intrauterine fetal death, preterm birth, and small-for-gestational age infants occurred in 18.1%, 4.1%, 32.7%, and 14.8%, respectively. Complication rates were similar in the first and consecutive pregnancies. Half of the women did not experience any pregnancy complication whereas 42.7% developed a complication during all pregnancies. Mean number of pregnancies was 2.4 and live births 1.7. CONCLUSION: In this SLE population with low disease activity, pregnancy complications were present irrespective of antiphospholipid antibody status. Furthermore, there were no differences in complication rates between the first and consecutive pregnancies as seen in healthy mothers. This information is useful for patient counseling.
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spelling pubmed-56378472017-11-01 Maternal and Perinatal Outcome in Women with Systemic Lupus Erythematosus: A Retrospective Bicenter Cohort Study Kroese, Sylvia J. Abheiden, Carolien N. H. Blomjous, Birgit S. van Laar, Jacob M. Derksen, Ronald W. H. M. Bultink, Irene E. M. Voskuyl, Alexandre E. Lely, A. Titia de Boer, Marjon A. de Vries, Johanna I. P. Fritsch-Stork, Ruth D. E. J Immunol Res Research Article OBJECTIVE: To investigate disease activity around and during pregnancy and pregnancy outcome in women with systemic lupus erythematosus (SLE) considering antiphospholipid antibody status. Moreover, differences between first and consecutive pregnancies were examined. METHODS: Pregnancies > 16 weeks gestation of SLE patients receiving joint care from rheumatologists and gynecologists in two tertiary centers in the Netherlands between 2000 and 2015 were included. Disease activity, flare rate, and pregnancy outcomes and complications were assessed. RESULTS: Ninety-six women (84% Caucasian) with 144 pregnancies were included. The median SLE(P)DAI score was 2 before, during, and after pregnancy. Flare rates were 6.3%, 20.1%, and 15.3%, respectively. Severe hypertensive disorder of pregnancy, intrauterine fetal death, preterm birth, and small-for-gestational age infants occurred in 18.1%, 4.1%, 32.7%, and 14.8%, respectively. Complication rates were similar in the first and consecutive pregnancies. Half of the women did not experience any pregnancy complication whereas 42.7% developed a complication during all pregnancies. Mean number of pregnancies was 2.4 and live births 1.7. CONCLUSION: In this SLE population with low disease activity, pregnancy complications were present irrespective of antiphospholipid antibody status. Furthermore, there were no differences in complication rates between the first and consecutive pregnancies as seen in healthy mothers. This information is useful for patient counseling. Hindawi 2017 2017-09-28 /pmc/articles/PMC5637847/ /pubmed/29094052 http://dx.doi.org/10.1155/2017/8245879 Text en Copyright © 2017 Sylvia J. Kroese et al. http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Kroese, Sylvia J.
Abheiden, Carolien N. H.
Blomjous, Birgit S.
van Laar, Jacob M.
Derksen, Ronald W. H. M.
Bultink, Irene E. M.
Voskuyl, Alexandre E.
Lely, A. Titia
de Boer, Marjon A.
de Vries, Johanna I. P.
Fritsch-Stork, Ruth D. E.
Maternal and Perinatal Outcome in Women with Systemic Lupus Erythematosus: A Retrospective Bicenter Cohort Study
title Maternal and Perinatal Outcome in Women with Systemic Lupus Erythematosus: A Retrospective Bicenter Cohort Study
title_full Maternal and Perinatal Outcome in Women with Systemic Lupus Erythematosus: A Retrospective Bicenter Cohort Study
title_fullStr Maternal and Perinatal Outcome in Women with Systemic Lupus Erythematosus: A Retrospective Bicenter Cohort Study
title_full_unstemmed Maternal and Perinatal Outcome in Women with Systemic Lupus Erythematosus: A Retrospective Bicenter Cohort Study
title_short Maternal and Perinatal Outcome in Women with Systemic Lupus Erythematosus: A Retrospective Bicenter Cohort Study
title_sort maternal and perinatal outcome in women with systemic lupus erythematosus: a retrospective bicenter cohort study
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5637847/
https://www.ncbi.nlm.nih.gov/pubmed/29094052
http://dx.doi.org/10.1155/2017/8245879
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