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Concise Review: Stem Cells for Corneal Wound Healing

Corneal wound healing is a complex process that occurs in response to various injuries and commonly used refractive surgery. It is a significant clinical problem, which may lead to serious complications due to either incomplete (epithelial) or excessive (stromal) healing. Epithelial stem cells clear...

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Autores principales: Saghizadeh, Mehrnoosh, Kramerov, Andrei A., Svendsen, Clive N., Ljubimov, Alexander V.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5637932/
https://www.ncbi.nlm.nih.gov/pubmed/28748596
http://dx.doi.org/10.1002/stem.2667
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author Saghizadeh, Mehrnoosh
Kramerov, Andrei A.
Svendsen, Clive N.
Ljubimov, Alexander V.
author_facet Saghizadeh, Mehrnoosh
Kramerov, Andrei A.
Svendsen, Clive N.
Ljubimov, Alexander V.
author_sort Saghizadeh, Mehrnoosh
collection PubMed
description Corneal wound healing is a complex process that occurs in response to various injuries and commonly used refractive surgery. It is a significant clinical problem, which may lead to serious complications due to either incomplete (epithelial) or excessive (stromal) healing. Epithelial stem cells clearly play a role in this process, whereas the contribution of stromal and endothelial progenitors is less well studied. The available evidence on stem cell participation in corneal wound healing is reviewed, together with the data on the use of corneal and non‐corneal stem cells to facilitate this process in diseased or postsurgical conditions. Important aspects of corneal stem cell generation from alternative cell sources, including pluripotent stem cells, for possible transplantation upon corneal injuries or in disease conditions are also presented. Stem Cells 2017;35:2105–2114
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spelling pubmed-56379322017-10-25 Concise Review: Stem Cells for Corneal Wound Healing Saghizadeh, Mehrnoosh Kramerov, Andrei A. Svendsen, Clive N. Ljubimov, Alexander V. Stem Cells Tissue‐Specific Stem Cells Corneal wound healing is a complex process that occurs in response to various injuries and commonly used refractive surgery. It is a significant clinical problem, which may lead to serious complications due to either incomplete (epithelial) or excessive (stromal) healing. Epithelial stem cells clearly play a role in this process, whereas the contribution of stromal and endothelial progenitors is less well studied. The available evidence on stem cell participation in corneal wound healing is reviewed, together with the data on the use of corneal and non‐corneal stem cells to facilitate this process in diseased or postsurgical conditions. Important aspects of corneal stem cell generation from alternative cell sources, including pluripotent stem cells, for possible transplantation upon corneal injuries or in disease conditions are also presented. Stem Cells 2017;35:2105–2114 John Wiley and Sons Inc. 2017-07-26 2017-10 /pmc/articles/PMC5637932/ /pubmed/28748596 http://dx.doi.org/10.1002/stem.2667 Text en © 2017 The Authors STEM CELLS published by Wiley Periodicals, Inc. on behalf of AlphaMed Press This is an open access article under the terms of the Creative Commons Attribution‐NonCommercial (http://creativecommons.org/licenses/by-nc/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes.
spellingShingle Tissue‐Specific Stem Cells
Saghizadeh, Mehrnoosh
Kramerov, Andrei A.
Svendsen, Clive N.
Ljubimov, Alexander V.
Concise Review: Stem Cells for Corneal Wound Healing
title Concise Review: Stem Cells for Corneal Wound Healing
title_full Concise Review: Stem Cells for Corneal Wound Healing
title_fullStr Concise Review: Stem Cells for Corneal Wound Healing
title_full_unstemmed Concise Review: Stem Cells for Corneal Wound Healing
title_short Concise Review: Stem Cells for Corneal Wound Healing
title_sort concise review: stem cells for corneal wound healing
topic Tissue‐Specific Stem Cells
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5637932/
https://www.ncbi.nlm.nih.gov/pubmed/28748596
http://dx.doi.org/10.1002/stem.2667
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