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Biological and Clinical Implications of Lysozyme Deposition on Soft Contact Lenses
Within a few minutes of wear, contact lenses become rapidly coated with a variety of tear film components, including proteins, lipids, and mucins. Tears have a rich and complex composition, allowing a wide range of interactions and competitive processes, with the first event observed at the interfac...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Lippincott Williams & Wilkins
2015
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5638422/ https://www.ncbi.nlm.nih.gov/pubmed/26002002 http://dx.doi.org/10.1097/OPX.0000000000000615 |
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author | Omali, Negar Babaei Subbaraman, Lakshman N. Coles-Brennan, Chantal Fadli, Zohra Jones, Lyndon W. |
author_facet | Omali, Negar Babaei Subbaraman, Lakshman N. Coles-Brennan, Chantal Fadli, Zohra Jones, Lyndon W. |
author_sort | Omali, Negar Babaei |
collection | PubMed |
description | Within a few minutes of wear, contact lenses become rapidly coated with a variety of tear film components, including proteins, lipids, and mucins. Tears have a rich and complex composition, allowing a wide range of interactions and competitive processes, with the first event observed at the interface between a contact lens and tear fluid being protein adsorption. Protein adsorption on hydrogel contact lenses is a complex process involving a variety of factors relating to both the protein in question and the lens material. Among tear proteins, lysozyme is a major protein that has both antibacterial and anti-inflammatory functions. Contact lens materials that have high ionicity and high water content have an increased affinity to accumulate lysozyme during wear, when compared with other soft lens materials, notably silicone hydrogel lenses. This review provides an overview of tear film proteins, with a specific focus on lysozyme, and examines various factors that influence protein deposition on contact lenses. In addition, the impact of lysozyme deposition on various ocular physiological responses and bacterial adhesion to lenses and the interaction of lysozyme with other tear proteins are reviewed. This comprehensive review suggests that deposition of lysozyme on contact lens materials may provide a number of beneficial effects during contact lens wear. |
format | Online Article Text |
id | pubmed-5638422 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2015 |
publisher | Lippincott Williams & Wilkins |
record_format | MEDLINE/PubMed |
spelling | pubmed-56384222017-10-24 Biological and Clinical Implications of Lysozyme Deposition on Soft Contact Lenses Omali, Negar Babaei Subbaraman, Lakshman N. Coles-Brennan, Chantal Fadli, Zohra Jones, Lyndon W. Optom Vis Sci Review Within a few minutes of wear, contact lenses become rapidly coated with a variety of tear film components, including proteins, lipids, and mucins. Tears have a rich and complex composition, allowing a wide range of interactions and competitive processes, with the first event observed at the interface between a contact lens and tear fluid being protein adsorption. Protein adsorption on hydrogel contact lenses is a complex process involving a variety of factors relating to both the protein in question and the lens material. Among tear proteins, lysozyme is a major protein that has both antibacterial and anti-inflammatory functions. Contact lens materials that have high ionicity and high water content have an increased affinity to accumulate lysozyme during wear, when compared with other soft lens materials, notably silicone hydrogel lenses. This review provides an overview of tear film proteins, with a specific focus on lysozyme, and examines various factors that influence protein deposition on contact lenses. In addition, the impact of lysozyme deposition on various ocular physiological responses and bacterial adhesion to lenses and the interaction of lysozyme with other tear proteins are reviewed. This comprehensive review suggests that deposition of lysozyme on contact lens materials may provide a number of beneficial effects during contact lens wear. Lippincott Williams & Wilkins 2015-07 2015-07-01 /pmc/articles/PMC5638422/ /pubmed/26002002 http://dx.doi.org/10.1097/OPX.0000000000000615 Text en Copyright © 2015 American Academy of Optometry This is an open-access article distributed under the terms of the Creative Commons Attribution-Non Commercial-No Derivatives License 4.0 (CCBY-NC-ND) (http://creativecommons.org/licenses/by-nc-nd/4.0/) , where it is permissible to download and share the work provided it is properly cited. The work cannot be changed in any way or used commercially. |
spellingShingle | Review Omali, Negar Babaei Subbaraman, Lakshman N. Coles-Brennan, Chantal Fadli, Zohra Jones, Lyndon W. Biological and Clinical Implications of Lysozyme Deposition on Soft Contact Lenses |
title | Biological and Clinical Implications of Lysozyme Deposition on Soft Contact Lenses |
title_full | Biological and Clinical Implications of Lysozyme Deposition on Soft Contact Lenses |
title_fullStr | Biological and Clinical Implications of Lysozyme Deposition on Soft Contact Lenses |
title_full_unstemmed | Biological and Clinical Implications of Lysozyme Deposition on Soft Contact Lenses |
title_short | Biological and Clinical Implications of Lysozyme Deposition on Soft Contact Lenses |
title_sort | biological and clinical implications of lysozyme deposition on soft contact lenses |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5638422/ https://www.ncbi.nlm.nih.gov/pubmed/26002002 http://dx.doi.org/10.1097/OPX.0000000000000615 |
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