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Role of the N-terminus for the stability of an amyloid-β fibril with three-fold symmetry
A key player in Alzheimer’s disease is the peptide amyloid-beta (Aβ), whose aggregation into small soluble oligomers, protofilaments, and fibrils finally leads to plaque deposits in human brains. The aggregation behavior of Aβ is strongly modulated by the nature and composition of the peptide’s envi...
| Autores principales: | , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Public Library of Science
2017
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5638522/ https://www.ncbi.nlm.nih.gov/pubmed/29023579 http://dx.doi.org/10.1371/journal.pone.0186347 |