Low-affinity binding in cis to P2Y(2)R mediates force-dependent integrin activation during hantavirus infection

Pathogenic hantaviruses bind to the plexin-semaphorin-integrin (PSI) domain of inactive, β(3) integrins. Previous studies have implicated a cognate cis interaction between the bent conformation β(5)/β(3) integrins and an arginine-glycine-aspartic acid (RGD) sequence in the first extracellular loop o...

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Detalles Bibliográficos
Autores principales: Bondu, Virginie, Wu, Chenyu, Cao, Wenpeng, Simons, Peter C., Gillette, Jennifer, Zhu, Jieqing, Erb, Laurie, Zhang, X. Frank, Buranda, Tione
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The American Society for Cell Biology 2017
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5638590/
https://www.ncbi.nlm.nih.gov/pubmed/28835374
http://dx.doi.org/10.1091/mbc.E17-01-0082

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5638590/
https://www.ncbi.nlm.nih.gov/pubmed/28835374
http://dx.doi.org/10.1091/mbc.E17-01-0082

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