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Hepatitis virus infection and age-related cataract
This study was performed to investigate the relationships of hepatitis B (HBV) and hepatitis C virus (HCV) infection to age-related cataract, and to assess whether liver damage mediates the hepatitis-cataract association. This study analyzed data in the Korea National Health and Nutrition Examinatio...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5638795/ https://www.ncbi.nlm.nih.gov/pubmed/29026129 http://dx.doi.org/10.1038/s41598-017-13283-6 |
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author | Park, Sangshin Choi, Nam-Kyong |
author_facet | Park, Sangshin Choi, Nam-Kyong |
author_sort | Park, Sangshin |
collection | PubMed |
description | This study was performed to investigate the relationships of hepatitis B (HBV) and hepatitis C virus (HCV) infection to age-related cataract, and to assess whether liver damage mediates the hepatitis-cataract association. This study analyzed data in the Korea National Health and Nutrition Examination Survey 2010–2012 on 10,037 participants aged ≥40 years. We performed mediation analysis to address the contribution of serum markers of liver damage, high aspartate (AST, >49.9 IU/L) and alanine aminotransferase (ALT, >56.1 IU/L), to the relationships of HBV and HCV infection to cataract. Odds ratios (ORs) for nuclear and any cataract with HBV infection were 1.09 [95% confidence interval (95CI) = 1.02–1.16] and 1.07 (95CI = 1.00–1.14), respectively, compared to HBV uninfection; ORs with HCV infection were 1.35 (95CI = 1.18–1.55) and 1.40 (95CI = 1.12–1.76), respectively. High AST completely mediated the HBV infection-any cataract association. The significant relationships of HCV infection with nuclear and any cataract were formed only by their direct effects, not by mediation effects of high AST or ALT. HBV and HCV infection was significantly associated with nuclear and any cataract. High AST significantly mediates the effects of HBV infections on any cataract outcome, but the associations of HCV infection with nuclear and any cataract were not mediated by high AST or ALT. |
format | Online Article Text |
id | pubmed-5638795 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | Nature Publishing Group UK |
record_format | MEDLINE/PubMed |
spelling | pubmed-56387952017-10-18 Hepatitis virus infection and age-related cataract Park, Sangshin Choi, Nam-Kyong Sci Rep Article This study was performed to investigate the relationships of hepatitis B (HBV) and hepatitis C virus (HCV) infection to age-related cataract, and to assess whether liver damage mediates the hepatitis-cataract association. This study analyzed data in the Korea National Health and Nutrition Examination Survey 2010–2012 on 10,037 participants aged ≥40 years. We performed mediation analysis to address the contribution of serum markers of liver damage, high aspartate (AST, >49.9 IU/L) and alanine aminotransferase (ALT, >56.1 IU/L), to the relationships of HBV and HCV infection to cataract. Odds ratios (ORs) for nuclear and any cataract with HBV infection were 1.09 [95% confidence interval (95CI) = 1.02–1.16] and 1.07 (95CI = 1.00–1.14), respectively, compared to HBV uninfection; ORs with HCV infection were 1.35 (95CI = 1.18–1.55) and 1.40 (95CI = 1.12–1.76), respectively. High AST completely mediated the HBV infection-any cataract association. The significant relationships of HCV infection with nuclear and any cataract were formed only by their direct effects, not by mediation effects of high AST or ALT. HBV and HCV infection was significantly associated with nuclear and any cataract. High AST significantly mediates the effects of HBV infections on any cataract outcome, but the associations of HCV infection with nuclear and any cataract were not mediated by high AST or ALT. Nature Publishing Group UK 2017-10-12 /pmc/articles/PMC5638795/ /pubmed/29026129 http://dx.doi.org/10.1038/s41598-017-13283-6 Text en © The Author(s) 2017 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/. |
spellingShingle | Article Park, Sangshin Choi, Nam-Kyong Hepatitis virus infection and age-related cataract |
title | Hepatitis virus infection and age-related cataract |
title_full | Hepatitis virus infection and age-related cataract |
title_fullStr | Hepatitis virus infection and age-related cataract |
title_full_unstemmed | Hepatitis virus infection and age-related cataract |
title_short | Hepatitis virus infection and age-related cataract |
title_sort | hepatitis virus infection and age-related cataract |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5638795/ https://www.ncbi.nlm.nih.gov/pubmed/29026129 http://dx.doi.org/10.1038/s41598-017-13283-6 |
work_keys_str_mv | AT parksangshin hepatitisvirusinfectionandagerelatedcataract AT choinamkyong hepatitisvirusinfectionandagerelatedcataract |