Dual contribution of TRPV4 antagonism in the regulatory effect of vasoinhibins on blood-retinal barrier permeability: diabetic milieu makes a difference

Breakdown of the blood-retinal barrier (BRB), as occurs in diabetic retinopathy and other chronic retinal diseases, results in vasogenic edema and neural tissue damage, causing vision loss. Vasoinhibins are N-terminal fragments of prolactin that prevent BRB breakdown during diabetes. They modulate t...

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Detalles Bibliográficos
Autores principales: Arredondo Zamarripa, David, Noguez Imm, Ramsés, Bautista Cortés, Ana María, Vázquez Ruíz, Osvaldo, Bernardini, Michela, Fiorio Pla, Alessandra, Gkika, Dimitra, Prevarskaya, Natalia, López-Casillas, Fernando, Liedtke, Wolfgang, Clapp, Carmen, Thébault, Stéphanie
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5638810/
https://www.ncbi.nlm.nih.gov/pubmed/29026201
http://dx.doi.org/10.1038/s41598-017-13621-8

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