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Targeted delivery of celastrol to mesangial cells is effective against mesangioproliferative glomerulonephritis

Mesangial cells-mediated glomerulonephritis is a frequent cause of end-stage renal disease. Here, we show that celastrol is effective in treating both reversible and irreversible mesangioproliferative glomerulonephritis in rat models, but find that its off-target distributions cause severe systemic...

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Detalles Bibliográficos
Autores principales:	Guo, Ling, Luo, Shi, Du, Zhengwu, Zhou, Meiling, Li, Peiwen, Fu, Yao, Sun, Xun, Huang, Yuan, Zhang, Zhirong
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2017
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5638829/ https://www.ncbi.nlm.nih.gov/pubmed/29026082 http://dx.doi.org/10.1038/s41467-017-00834-8

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