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Primary Astrocytic Tumours and Paired Recurrences have Similar Biological Features in IDH1, TP53 and TERTp Mutation and MGMT, ATRX Loss

Astrocytic tumours are the most common type of primary malignant brain tumour. Most astrocytic tumours will recur at some point after surgery. Currently, the combination of radiotherapy and chemotherapy does not prevent the recurrence of astrocytic tumours. In this study, we investigated the consist...

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Autores principales: Li, Xia, Wei, Jie, Liu, Yixiong, Li, Peifeng, Fan, Linni, Wang, Yingmei, Li, Mingyang, Zhao, Danhui, Yu, Zhou, Ye, Jing, Guo, Ying, Yan, Qingguo, Guo, Shuangping, Wang, Zhe
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5638900/
https://www.ncbi.nlm.nih.gov/pubmed/29026176
http://dx.doi.org/10.1038/s41598-017-13272-9
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author Li, Xia
Wei, Jie
Liu, Yixiong
Li, Peifeng
Fan, Linni
Wang, Yingmei
Li, Mingyang
Zhao, Danhui
Yu, Zhou
Ye, Jing
Guo, Ying
Yan, Qingguo
Guo, Shuangping
Wang, Zhe
author_facet Li, Xia
Wei, Jie
Liu, Yixiong
Li, Peifeng
Fan, Linni
Wang, Yingmei
Li, Mingyang
Zhao, Danhui
Yu, Zhou
Ye, Jing
Guo, Ying
Yan, Qingguo
Guo, Shuangping
Wang, Zhe
author_sort Li, Xia
collection PubMed
description Astrocytic tumours are the most common type of primary malignant brain tumour. Most astrocytic tumours will recur at some point after surgery. Currently, the combination of radiotherapy and chemotherapy does not prevent the recurrence of astrocytic tumours. In this study, we investigated the consistency in isocitrate dehydrogenase 1 (IDH1), tumour protein p53 (TP53) and telomerase reverse transcriptase promoter (TERTp) mutations during astrocytic tumour recurrence. We also evaluated the protein loss of O-6-methylguanine-DNA methyltransferase (MGMT) and alpha-thalassemia/mental retardation, X-linked (ATRX) during disease recurrence. We then determined the prognostic significance of these findings in terms of progression-free survival (PFS) using Kaplan-Meier analysis and Cox regression models. Our results showed that in most cases, IDH1, TP53 and TERTp mutation status and MGMT and ATRX protein expression levels were stable during recurrence, which may indicate that these alterations occurred early in astrocytic tumour development. Furthermore, in IDH1 wild type group, the patients who were negative for MGMT and had a low Ki67 index showed a longer PFS. Therefore, we suggest that IDH1 mutation combined with MGMT expression level and Ki67 index might be an effective biomarker panel for evaluating the PFS of patients with astrocytic tumours.
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spelling pubmed-56389002017-10-18 Primary Astrocytic Tumours and Paired Recurrences have Similar Biological Features in IDH1, TP53 and TERTp Mutation and MGMT, ATRX Loss Li, Xia Wei, Jie Liu, Yixiong Li, Peifeng Fan, Linni Wang, Yingmei Li, Mingyang Zhao, Danhui Yu, Zhou Ye, Jing Guo, Ying Yan, Qingguo Guo, Shuangping Wang, Zhe Sci Rep Article Astrocytic tumours are the most common type of primary malignant brain tumour. Most astrocytic tumours will recur at some point after surgery. Currently, the combination of radiotherapy and chemotherapy does not prevent the recurrence of astrocytic tumours. In this study, we investigated the consistency in isocitrate dehydrogenase 1 (IDH1), tumour protein p53 (TP53) and telomerase reverse transcriptase promoter (TERTp) mutations during astrocytic tumour recurrence. We also evaluated the protein loss of O-6-methylguanine-DNA methyltransferase (MGMT) and alpha-thalassemia/mental retardation, X-linked (ATRX) during disease recurrence. We then determined the prognostic significance of these findings in terms of progression-free survival (PFS) using Kaplan-Meier analysis and Cox regression models. Our results showed that in most cases, IDH1, TP53 and TERTp mutation status and MGMT and ATRX protein expression levels were stable during recurrence, which may indicate that these alterations occurred early in astrocytic tumour development. Furthermore, in IDH1 wild type group, the patients who were negative for MGMT and had a low Ki67 index showed a longer PFS. Therefore, we suggest that IDH1 mutation combined with MGMT expression level and Ki67 index might be an effective biomarker panel for evaluating the PFS of patients with astrocytic tumours. Nature Publishing Group UK 2017-10-12 /pmc/articles/PMC5638900/ /pubmed/29026176 http://dx.doi.org/10.1038/s41598-017-13272-9 Text en © The Author(s) 2017 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
spellingShingle Article
Li, Xia
Wei, Jie
Liu, Yixiong
Li, Peifeng
Fan, Linni
Wang, Yingmei
Li, Mingyang
Zhao, Danhui
Yu, Zhou
Ye, Jing
Guo, Ying
Yan, Qingguo
Guo, Shuangping
Wang, Zhe
Primary Astrocytic Tumours and Paired Recurrences have Similar Biological Features in IDH1, TP53 and TERTp Mutation and MGMT, ATRX Loss
title Primary Astrocytic Tumours and Paired Recurrences have Similar Biological Features in IDH1, TP53 and TERTp Mutation and MGMT, ATRX Loss
title_full Primary Astrocytic Tumours and Paired Recurrences have Similar Biological Features in IDH1, TP53 and TERTp Mutation and MGMT, ATRX Loss
title_fullStr Primary Astrocytic Tumours and Paired Recurrences have Similar Biological Features in IDH1, TP53 and TERTp Mutation and MGMT, ATRX Loss
title_full_unstemmed Primary Astrocytic Tumours and Paired Recurrences have Similar Biological Features in IDH1, TP53 and TERTp Mutation and MGMT, ATRX Loss
title_short Primary Astrocytic Tumours and Paired Recurrences have Similar Biological Features in IDH1, TP53 and TERTp Mutation and MGMT, ATRX Loss
title_sort primary astrocytic tumours and paired recurrences have similar biological features in idh1, tp53 and tertp mutation and mgmt, atrx loss
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5638900/
https://www.ncbi.nlm.nih.gov/pubmed/29026176
http://dx.doi.org/10.1038/s41598-017-13272-9
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