CETSA quantitatively verifies in vivo target engagement of novel RIPK1 inhibitors in various biospecimens

The proof of target engagement (TE) is a key element for evaluating potential investment in drug development. The cellular thermal shift assay (CETSA) is expected to facilitate direct measurement of intracellular TE at all stages of drug development. However, there have been no reports of applying t...

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Detalles Bibliográficos
Autores principales: Ishii, Tsuyoshi, Okai, Takuro, Iwatani-Yoshihara, Misa, Mochizuki, Manabu, Unno, Satoko, Kuno, Masako, Yoshikawa, Masato, Shibata, Sachio, Nakakariya, Masanori, Yogo, Takatoshi, Kawamoto, Tomohiro
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5638916/
https://www.ncbi.nlm.nih.gov/pubmed/29026104
http://dx.doi.org/10.1038/s41598-017-12513-1

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5638916/
https://www.ncbi.nlm.nih.gov/pubmed/29026104
http://dx.doi.org/10.1038/s41598-017-12513-1

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