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CETSA quantitatively verifies in vivo target engagement of novel RIPK1 inhibitors in various biospecimens
The proof of target engagement (TE) is a key element for evaluating potential investment in drug development. The cellular thermal shift assay (CETSA) is expected to facilitate direct measurement of intracellular TE at all stages of drug development. However, there have been no reports of applying t...
| Autores principales: | , , , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Nature Publishing Group UK
2017
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5638916/ https://www.ncbi.nlm.nih.gov/pubmed/29026104 http://dx.doi.org/10.1038/s41598-017-12513-1 |