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Associations of interactions between NLRP3 SNPs and HLA mismatch with acute and extensive chronic graft-versus-host diseases

HLA matching is a well-known genetic requirement for successful bone marrow transplantation (BMT). However, the importance of non-HLA single-nucleotide polymorphisms (SNPs) remains poorly understood. The NLR family pyrin domain–containing 3 (NLRP3) inflammasome, a key regulator of innate immunity, i...

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Detalles Bibliográficos
Autores principales: Takahashi, Hidekazu, Okayama, Naoko, Yamaguchi, Natsu, Miyahara, Yuta, Morishima, Yasuo, Suehiro, Yutaka, Yamasaki, Takahiro, Tamada, Koji, Takahashi, Satoshi, Tojo, Arinobu, Asano, Shigetaka, Tanabe, Tsuyoshi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5638959/
https://www.ncbi.nlm.nih.gov/pubmed/29026154
http://dx.doi.org/10.1038/s41598-017-13506-w