Evidence for Hypothalamus-Pituitary-Adrenal Axis and Immune Alterations at Prodrome of Psychosis in Males

We aimed to investigate the inflammatory substrate in psychosis by evaluating both the Hypothalamus-Pituitary-Adrenal axis function and immune state at prodrome. This involved the recruitment of Ultra High Risk (UHR) of Psychosis subjects, Healthy Controls (HC) and patients with established Schizoph...

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Autores principales: Karanikas, Evangelos, Ntouros, Evangelos, Oikonomou, Dimitrios, Floros, Georgios, Griveas, Ioannis, Garyfallos, Georgios
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Korean Neuropsychiatric Association 2017
Materias:
Brief Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5639142/
https://www.ncbi.nlm.nih.gov/pubmed/29042899
http://dx.doi.org/10.4306/pi.2017.14.5.703
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author Karanikas, Evangelos
Ntouros, Evangelos
Oikonomou, Dimitrios
Floros, Georgios
Griveas, Ioannis
Garyfallos, Georgios
author_facet Karanikas, Evangelos
Ntouros, Evangelos
Oikonomou, Dimitrios
Floros, Georgios
Griveas, Ioannis
Garyfallos, Georgios
author_sort Karanikas, Evangelos
collection PubMed
description We aimed to investigate the inflammatory substrate in psychosis by evaluating both the Hypothalamus-Pituitary-Adrenal axis function and immune state at prodrome. This involved the recruitment of Ultra High Risk (UHR) of Psychosis subjects, Healthy Controls (HC) and patients with established Schizophrenia (CHRON). Serum cortisol at 3 different times throughout the day was measured. The Dexamethasone Suppression Test was performed plus 12 circulating cytokines were measured. The UHR subjects presented increased IL-4 levels compared with both the HC and CHRON patients. In contrast the UHR differed only from the CHRON group regarding the endocrine parameters. In conclusion, IL-4 appears to play a key role at prodrome.
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spelling pubmed-56391422017-10-17 Evidence for Hypothalamus-Pituitary-Adrenal Axis and Immune Alterations at Prodrome of Psychosis in Males Karanikas, Evangelos Ntouros, Evangelos Oikonomou, Dimitrios Floros, Georgios Griveas, Ioannis Garyfallos, Georgios Psychiatry Investig Brief Report We aimed to investigate the inflammatory substrate in psychosis by evaluating both the Hypothalamus-Pituitary-Adrenal axis function and immune state at prodrome. This involved the recruitment of Ultra High Risk (UHR) of Psychosis subjects, Healthy Controls (HC) and patients with established Schizophrenia (CHRON). Serum cortisol at 3 different times throughout the day was measured. The Dexamethasone Suppression Test was performed plus 12 circulating cytokines were measured. The UHR subjects presented increased IL-4 levels compared with both the HC and CHRON patients. In contrast the UHR differed only from the CHRON group regarding the endocrine parameters. In conclusion, IL-4 appears to play a key role at prodrome. Korean Neuropsychiatric Association 2017-09 2017-09-11 /pmc/articles/PMC5639142/ /pubmed/29042899 http://dx.doi.org/10.4306/pi.2017.14.5.703 Text en Copyright © 2017 Korean Neuropsychiatric Association http://creativecommons.org/licenses/by-nc/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Brief Report
Karanikas, Evangelos
Ntouros, Evangelos
Oikonomou, Dimitrios
Floros, Georgios
Griveas, Ioannis
Garyfallos, Georgios
Evidence for Hypothalamus-Pituitary-Adrenal Axis and Immune Alterations at Prodrome of Psychosis in Males
title Evidence for Hypothalamus-Pituitary-Adrenal Axis and Immune Alterations at Prodrome of Psychosis in Males
title_full Evidence for Hypothalamus-Pituitary-Adrenal Axis and Immune Alterations at Prodrome of Psychosis in Males
title_fullStr Evidence for Hypothalamus-Pituitary-Adrenal Axis and Immune Alterations at Prodrome of Psychosis in Males
title_full_unstemmed Evidence for Hypothalamus-Pituitary-Adrenal Axis and Immune Alterations at Prodrome of Psychosis in Males
title_short Evidence for Hypothalamus-Pituitary-Adrenal Axis and Immune Alterations at Prodrome of Psychosis in Males
title_sort evidence for hypothalamus-pituitary-adrenal axis and immune alterations at prodrome of psychosis in males
topic Brief Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5639142/
https://www.ncbi.nlm.nih.gov/pubmed/29042899
http://dx.doi.org/10.4306/pi.2017.14.5.703
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